PMID: 9177961Apr 1, 1997Paper

Five-day versus ten-day treatment of acute otitis media with cefprozil

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
D A KafetzisL Mitropoulos

Abstract

A randomized comparative clinical trial was conducted to investigate the possibility of decreasing the duration of treatment of acute otitis media by comparing the clinical outcome and safety of a five-day and a ten-day course of cefprozil. A total of 708 pediatric patients were enrolled in the study, 560 of whom were evaluable for efficacy. Cefprozil was found to be completely effective in 87.1% of cases after five days of treatment, and in 91.2% after ten days of treatment. Of 19 patients with three or more previous episodes of acute otitis media, ten patients in the ten-day treatment group had a 100% cure rate, while in the five-day group four experienced cure, three improvement, and two failure. A five-day course of treatment with cefprozil can be recommended only if children have no history of recurrent acute otitis media.

References

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Citations

Sep 28, 2000·International Journal of Pediatric Otorhinolaryngology·K Roos, P Larsson
May 20, 2000·The Pediatric Infectious Disease Journal·R CohenF de La Rocque
Apr 11, 2008·International Journal of Pediatric Otorhinolaryngology·Michael E Pichichero, Janet R Casey
Oct 16, 2015·Journal of the American Chemical Society·Tiezheng JiaPatrick J Walsh
Feb 28, 2007·Clinical Pediatrics·Stephanie M ChandlerDavid P McCormick
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Anita KozyrskyjKrystal Harvey

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