Five-minute knee MRI for simultaneous morphometry and T2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T

Journal of Magnetic Resonance Imaging : JMRI
Akshay S ChaudhariBrian A Hargreaves

Abstract

Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times. To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T2 relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS). Prospective. Fifteen healthy volunteers for morphometry and T2 measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment. A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T. Flip angle simulations evaluated tissue signals and sensitivity of T2 measurements. Morphometry and T2 reproducibility was compared against morphometry-optimized and relaxometry-optimized sequences. Repeatability was assessed by scanning five volunteers twice. MOAKS reproducibility was compared to MOAKS derived from a clinical knee MRI protocol by two readers. Coefficients of variation (CVs), concordance confidence intervals (CCI), and Wilcoxon signed-rank tests compared morphometry and relaxometry measurements with their reference standards. DESS MOAKS positive percent agreement (PPA), negative percentage agreement (NPA), and int...Continue Reading

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Citations

Mar 28, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Akshay S ChaudhariBrian A Hargreaves
Jul 18, 2019·Journal of Magnetic Resonance Imaging : JMRI·Akshay S ChaudhariBrian A Hargreaves
Oct 24, 2019·Current Opinion in Rheumatology·Vladimir JurasRavinder R Regatte
May 20, 2020·Radiology·Frank W RoemerAli Guermazi
Aug 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Akshay S ChaudhariCurtis P Langlotz
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Fang Liu
Nov 23, 2019·Journal of Magnetic Resonance Imaging : JMRI·Akshay S ChaudhariBrian A Hargreaves
Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jonathan I TamirShreyas S Vasanawala
Oct 8, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jaclyn A KonopkaJason L Dragoo
Oct 31, 2020·The Journal of Knee Surgery·Russell C FritzRobert D Boutin
Feb 15, 2021·Arthritis Research & Therapy·Bas A de VriesEdwin H G Oei
Dec 27, 2019·Osteoarthritis and Cartilage·R KijowskiA Guermazi
Jun 21, 2021·International Journal of Computer Assisted Radiology and Surgery·Jonas DenckEva Rothgang
Sep 22, 2021·Seminars in Musculoskeletal Radiology·Richard Kijowski
Jul 22, 2021·AJR. American Journal of Roentgenology·Jacob ThoenenFeliks Kogan

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