Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri

Marine Drugs
Wen-Jian LanHou-Jin Li

Abstract

The marine fungus Neosartorya pseudofischeri was isolated from Acanthaster planci from the South China Sea. In a preliminary bioactivity screening, the crude methanol extract of the fungal mycelia showed significant inhibitory activity against the Sf9 cell line from the fall armyworm Spodoptera frugiperda. Five novel compounds, including 5-olefin phenylpyropene A (1), 13-dehydroxylpyripyropene A (4), deacetylsesquiterpene (7), 5-formyl-6-hydroxy-8-isopropyl-2- naphthoic acid (9) and 6,8-dihydroxy-3-((1E,3E)-penta-1,3-dien-1-yl)isochroman-1-one (10), together with eleven known compounds, phenylpyropene A (2) and C (3), pyripyropene A (5), 7-deacetylpyripyropene A (6), (1S,2R,4aR,5R,8R,8aR)-1,8a-dihydroxy-2-acetoxy-3,8-dimethyl-5- (prop-1-en-2-yl)-1,2,4a, 5,6,7,8,8a-octahydronaphthalene (8), isochaetominine C (11), trichodermamide A (12), indolyl-3-acetic acid methyl ester (13), 1-acetyl-β-carboline (14), 1,2,3,4-tetrahydro-6-hydroxyl-2-methyl-l,3,4-trioxopyrazino[l,2-a]-indole (15) and fumiquinazoline F (16), were obtained. The structures of these compounds were determined mainly by MS and NMR data. The absolute configuration of 9 was assigned by the single-crystal X-ray diffraction studies. Compounds 1-11 and 15 showed signific...Continue Reading

References

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Citations

Nov 22, 2016·Scientific Reports·Jingzu SunXingzhong Liu
Nov 3, 2016·Chemistry & Biodiversity·Qing-Xiang CaoHou-Jin Li
Jun 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anders BrobergJolanta J Levenfors
Aug 10, 2018·Natural Product Reports·Diana I S P ResendeMadalena M M Pinto
Oct 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·You-Min YingZha-Jun Zhan
Jun 22, 2019·The Journal of Antibiotics·Kimihiko GotoSatoshi Ōmura
Jun 24, 2020·Marine Drugs·Minghua JiangSenhua Chen
Feb 3, 2018·International Journal of Oncology·Junxiong ChenHuanliang Liu
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Dec 16, 2020·Organic & Biomolecular Chemistry·Minghua JiangSenhua Chen

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Datasets Mentioned

BETA
KF999816

Methods Mentioned

BETA
transgenic
NMR
X-ray
FCS

Software Mentioned

ORTEP

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