PMID: 2493143Jan 1, 1989Paper

Five patients with Rasmussen's syndrome investigated by single-photon-emission computed tomography

Nuclear Medicine Communications
R EnglishG Stores

Abstract

Five patients with Rasmussen's syndrome (sometimes known as smouldering encephalitis), are presented. This rare form of childhood epilepsy is characterized by intractable partial seizures with progressive neurological and mental impairment. Diagnostic brain biopsy shows the histological changes of active encephalitis, consistent with a viral infection. Although the raised cerebrospinal fluid (CSF) complement and interferon levels seen in some patients support this hypothesis, no infective agent has yet been isolated. All five patients were investigated by transmission computed tomography (CT) of the head, electroencephalography (EEG) and cerebral single-photon-emission computed tomography (SPECT) using 99Tcm-hexamethylpropylenamine oxime (HMPAO) and in addition 123I-amphetamine (IMP) in Patient 1. 99Tcm-HMPAO is now regarded as reflecting cerebral perfusion, whereas the uptake of 123I-amphetamine is more dependent on cell function. In all patients SPECT imaging demonstrated an area of hypoperfusion/hypometabolism which corresponded to the anatomical localization of the epiletogenic foci found by clinical assessment, EEG and CT. In all cases the SPECT study also demonstrated a more extensive area of abnormality than CT, and in t...Continue Reading

Citations

Aug 10, 2000·Italian Journal of Neurological Sciences·F PaladinR Mameli
Jul 2, 2005·Der Nervenarzt·C G Bien, C E Elger
Jul 6, 2000·European Radiology·D Türkdogan-SözüerM N Pamir
May 17, 2002·Brain & Development·Hideaki IshibashiAndrew C Papanicolaou
Apr 15, 2011·International Journal of Molecular Imaging·Sita JayalakshmiManas Panigrahi
Apr 6, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jorge G BurneoAndrew Parrent
Oct 1, 1994·Journal of Child Neurology·A S Harvey, S F Berkovic
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