Five threads: How U-shaped thinking weaves together dogs, men, selenium, and prostate cancer risk

Free Radical Biology & Medicine
David J Waters, Emily C Chiang

Abstract

Prostate cancer is one of the leading causes of cancer-related mortality among men living in developed countries, making the development of safe, practical approaches to prostate cancer risk reduction a high research priority. The relationship between prostate cancer risk and selenium, an essential nutrient required for a number of metabolically important enzymes including glutathione peroxidases, has been investigated, but a satisfactory integration of results has proven elusive. Dogs, like men, naturally develop prostate cancer during aging, providing an appropriate context to study the effects of selenium supplementation on the dysregulation of homeostasis that drives cancer development within the aging prostate. In this paper, we summarize the translational significance of research results gained from dog studies on selenium and prostate cancer risk. Our discovery of a U-shaped dose-response between toenail selenium concentration and prostatic DNA damage in dogs remarkably parallels data on the relationship between selenium status and prostate cancer risk in men. Notably, the dog U-curve provides a plausible explanation for the unanticipated increase in prostate cancer incidence among men with highest baseline selenium who ...Continue Reading

Citations

Dec 22, 2019·Nutrients·Nishi KarunasingheLynnette R Ferguson
Jul 4, 2019·Current Pharmaceutical Design·Harry RobberechtNina Hermans
Sep 13, 2020·European Journal of Nutrition·Barbara R CardosoHelen Macpherson
Feb 11, 2021·Animals : an Open Access Journal From MDPI·Viola ZentrichováSimona Kovaříková
May 25, 2018·Free Radical Biology & Medicine·Kristin M PetersPetra A Tsuji
Aug 3, 2021·The Journal of Nutritional Biochemistry·Barbara Rita CardosoBlaine Russel Roberts
Nov 3, 2021·Critical Reviews in Clinical Laboratory Sciences·Sarahi Jaramillo OrtizFrédéric J Tessier

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