Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G)

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Yuji MiuraIchinosuke Hyodo

Abstract

Five-weekly S-1 plus cisplatin (SP) therapy is the standard care for advanced gastric or esophagogastric junction cancer (GC/EGJC) in East Asia. However, its efficacy and safety when combined with trastuzumab therapy for human epidermal growth factor receptor 2 (HER2)-positive advanced GC/EGJC remains unclear. Patients received 5-weekly SP therapy (S-1 at 40-60 mg twice daily for 21 days plus cisplatin at 60 mg/m2 on day 8, every 5 weeks) plus trastuzumab therapy (first dose of 8 mg/kg, then 6 mg/kg every 3 weeks). The primary end point was the response rate, and the secondary end points included progression-free survival, overall survival, safety, and serum biomarker levels. Forty-four patients were enrolled. The response rate, progression-free survival, and overall survival were 61% (95% confidence interval 46-76%), 5.9 months, and 16.5 months respectively. The commonest grade 3 or grade 4 adverse events were neutropenia (30%) and anorexia (25%). A significantly higher response rate (92% vs 43%; P = 0.008) and longer progression-free survival (median 14.5 months vs 4.2 months; P = 0.028) were observed in patients with high (n = 14) compared with low (n = 17) pretreatment serum neuregulin 1 levels. Five-weekly SP therapy combi...Continue Reading

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Citations

Oct 18, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shusuke YagiYusuke Horiuchi
Feb 16, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
May 19, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daisuke TakahariKensei Yamaguchi
Mar 27, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Akitaka MakiyamaKei Muro
Aug 9, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sebastian MondacaYelena Y Janjigian
Dec 7, 2018·Japanese Journal of Clinical Oncology·Hiroyuki AraiTakako Eguchi Nakajima
Apr 15, 2021·AJR. American Journal of Roentgenology·Huiping ZhaoJianbo Gao
Apr 25, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Yinxing ZhuWenwen Zhang
Aug 24, 2021·Current Treatment Options in Oncology·Brian C Grieb, Rajiv Agarwal

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