Abstract
Five-weekly S-1 plus cisplatin (SP) therapy is the standard care for advanced gastric or esophagogastric junction cancer (GC/EGJC) in East Asia. However, its efficacy and safety when combined with trastuzumab therapy for human epidermal growth factor receptor 2 (HER2)-positive advanced GC/EGJC remains unclear. Patients received 5-weekly SP therapy (S-1 at 40-60 mg twice daily for 21 days plus cisplatin at 60 mg/m2 on day 8, every 5 weeks) plus trastuzumab therapy (first dose of 8 mg/kg, then 6 mg/kg every 3 weeks). The primary end point was the response rate, and the secondary end points included progression-free survival, overall survival, safety, and serum biomarker levels. Forty-four patients were enrolled. The response rate, progression-free survival, and overall survival were 61% (95% confidence interval 46-76%), 5.9 months, and 16.5 months respectively. The commonest grade 3 or grade 4 adverse events were neutropenia (30%) and anorexia (25%). A significantly higher response rate (92% vs 43%; P = 0.008) and longer progression-free survival (median 14.5 months vs 4.2 months; P = 0.028) were observed in patients with high (n = 14) compared with low (n = 17) pretreatment serum neuregulin 1 levels. Five-weekly SP therapy combi...Continue Reading
References
Jul 23, 2005·Clinical & Experimental Metastasis·Christophe Stove, Marc Bracke
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lyndsay N HarrisEric P Winer
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·M Breuleux
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Enrique de AlavaAtanasio Pandiella
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph A RitterCarlos L Arteaga
Feb 20, 2008·The Lancet Oncology·Wasaburo KoizumiMasahiro Takeuchi
Mar 5, 2008·Cancer Research·David L ShattuckColleen Sweeney
Jun 6, 2009·Experimental Cell Research·Xiaoli ShiXiaohong Fang
Aug 24, 2010·Lancet·Yung-Jue BangUNKNOWN ToGA Trial Investigators
Aug 17, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuYoon-Koo Kang
Dec 20, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Akira SawakiAtsushi Ohtsu
Jul 12, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kensei YamaguchiAtsushi Ohtsu
Jan 30, 2014·British Journal of Cancer·Y KurokawaH Furukawa
Feb 22, 2014·Journal of Gastroenterology·Katsunobu OyamaTetsuo Ohta
Aug 16, 2014·Biomarkers in Medicine·Zhi PengLin Shen
Nov 9, 2014·Journal of Gastroenterology·Myoung-Eun HanSae-Ock Oh
Feb 24, 2015·Journal of Gastroenterology·Jun ZhouLin Shen
Jul 29, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M-H RyuUNKNOWN SOS study investigators
Jan 13, 2016·Acta Oncologica·Mayuko SaitoYasuhisa Shinomura
Feb 20, 2016·Journal of Gastroenterology·Takeshi YamadaIchisnosuke Hyodo
Citations
May 17, 2018·Medicine·Giandomenico RovielloMichele Aieta
Oct 18, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shusuke YagiYusuke Horiuchi
Nov 27, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K MuroJ-Y Douillard
Jan 19, 2019·Molecular and Clinical Oncology·Michio KimuraTomoaki Yoshimura
Feb 16, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jan 12, 2020·Surgical Case Reports·Yuki KatsuraYuichi Shibuya
Feb 3, 2018·Chemotherapy·Hideki NagaseJunji Uchida
May 19, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daisuke TakahariKensei Yamaguchi
Mar 27, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Akitaka MakiyamaKei Muro
Aug 9, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sebastian MondacaYelena Y Janjigian
Dec 7, 2018·Japanese Journal of Clinical Oncology·Hiroyuki AraiTakako Eguchi Nakajima
Jun 26, 2018·The Tohoku Journal of Experimental Medicine·Akira OkitaChikashi Ishioka
Jan 1, 2018·Cancer Chemotherapy and Pharmacology·Shunsuke KagawaToshiyoshi Fujiwara
Apr 15, 2021·AJR. American Journal of Roentgenology·Huiping ZhaoJianbo Gao
Apr 25, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Yinxing ZhuWenwen Zhang
Aug 24, 2021·Current Treatment Options in Oncology·Brian C Grieb, Rajiv Agarwal
Jun 13, 2019·Nano Letters·Wenjuan MaYunfeng Lin