Five-year clinical outcomes in patients with significant coronary artery spasm: A propensity score-matched analysis

International Journal of Cardiology
Byoung Geol ChoiDong Joo Oh

Abstract

Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. We evaluated the prevalence of CAS and the impact of CAS on 5-year clinical outcomes in a series of Asian CAS patients documented by intracoronary acetylcholine (Ach) provocation test. A total of 1413 consecutive patients without significant coronary artery disease (CAD) who underwent Ach provocation test between Nov. 2004 and Oct. 2008 were enrolled. Significant CAS was defined as >70% of narrowing by incremental intracoronary injection of 20, 50 and 100 μg. Patients were divided into two groups based on the presence of significant CAS (the non-CAS group: n=640, the CAS group; n=773). To adjust potential confounders, a propensity score matched (PSM) analysis was performed using the logistic regression model. A total of 54.7% (773/1413) patients were diagnosed as CAS documented by Ach provocation test. After PSM analysis, 2 propensity-matched groups (451 pairs, n=902, C-statistic=0.677) were generated. Despite of similar incidence of individual hard endpoints including morta...Continue Reading

References

Jan 1, 1993·Circulation·M Sugiishi, F Takatsu
Sep 22, 2007·The American Journal of Cardiology·Jin Won KimDong Joo Oh
Jun 5, 2008·Journal of cardiology·Hirofumi YasueYuji Mizuno
Aug 13, 2009·Clinical and Experimental Pharmacology & Physiology·Kang-Yin ChenDong-Joo Oh
Jan 28, 2012·International Journal of Cardiology·Yae Min ParkEak Kyun Shin

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Citations

May 26, 2015·International Journal of Cardiology·Alicia Mateo MartínezDaniel Saura Espín
Jul 23, 2016·Journal of the American Heart Association·Byoung Geol ChoiDong Joo Oh
Feb 24, 2020·The Korean Journal of Internal Medicine·Sung Eun KimSang Hong Baek
Oct 11, 2016·Korean Circulation Journal·Byoung Geol ChoiDong Joo Oh

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