Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson's Disease

Parkinson's Disease
Sheng-Tzung TsaiShin-Yuan Chen

Abstract

Studies comparing long-term outcomes between general anesthesia (GA) and local anesthesia (LA) for STN-DBS in Parkinson's disease (PD) are lacking. Whether patients who received STN-DBS in GA could get the same benefit without compromising electrophysiological recording is debated. We compared five-year outcomes for different anesthetic methods (GA vs LA) during STN-DBS for PD. Thirty-six consecutive PD patients with similar preoperative characteristics, including age, disease duration, and severity, underwent the same surgical procedures except the GA (n=22) group with inhalational anesthesia and LA (n=14) with local anesthesia during microelectrode recording and intraoperative macrostimulation test. Surgical outcome evaluations included Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental Status Examinations, and the Beck Depression Inventory. Stimulation parameters and coordinates of STN targeting were also collected. Both groups attained similar benefits in UPDRS part III from STN-DBS (GA 43.2 ± 14.1% vs. LA 46.8 ± 13.8% decrease, p=0.45; DBS on/Med off vs. DBS off/Med off) and no difference in reduction of levodopa equivalent doses (GA 47.56 ± 18.98% vs. LA 51.37 ± 31.73%, p=0.51) at the five-year follow-up. In te...Continue Reading

References

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Citations

Nov 11, 2019·Brain Sciences·Lorena Vega-ZelayaJesús Pastor
Dec 13, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Jun WangShao-Wu Ou
Feb 11, 2021·Neurology and Therapy·Pepijn van den MunckhofP Richard Schuurman
Oct 30, 2021·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·S V AsriyantsI N Pronin

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS
SPSS statistics
GA

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