Five-year experience with risedronate therapy for patients with increased fracture risk: a practice-based observational study

Biological & Pharmaceutical Bulletin
Masayuki Takakuwa, Jun Iwamoto

Abstract

The purpose of this practice-based observational study was to examine the effects of long-term treatment with risedronate in patients with an increased fracture risk. Seventy patients (4 men and 66 postmenopausal women; mean age, 68.0 years) with osteoporosis or osteopenia and clinical risk factors for fractures were treated with risedronate at either 2.5 mg/d or 17.5 mg/week for 5 years. The bone mineral density (BMD) of the lumbar spine and proximal femur, and the structural geometric parameters of the proximal femur were evaluated by dual-energy X-ray absorptiometry with advanced hip assessment software at baseline and after each year of treatment. The lumbar spine BMD rapidly increased during the first year of the treatment and steadily increased throughout the 5-year treatment period. The BMD of the femoral neck and total hip also significantly increased during the first 3 and 2 years of treatment, respectively, then gradually declined and reached the baseline level after 5 years of treatment. The cross-sectional moment of inertia, cross-sectional area, and mean width of the femoral neck region of interest significantly increased during the first 2 years, and these increases were maintained throughout the 5-year treatment ...Continue Reading

References

Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T YoshikawaD B Burr
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Oct 31, 2001·Journal of Bone and Mineral Metabolism·H OrimoH Kishimoto
May 4, 2004·Current Medical Research and Opinion·Christian RouxNelson B Watts
Sep 30, 2004·Calcified Tissue International·D D MellströmA A Chines
Feb 1, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K G FaulknerL Del Rio
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Feb 7, 2008·The Cochrane Database of Systematic Reviews·G WellsP Tugwell
Mar 19, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas J BeckZhao Chen
Apr 16, 2009·Clinical Drug Investigation·Zhao-Ming Zhong, Jian-Ting Chen
Sep 16, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneUNKNOWN American Society for Bone and Mineral Research
Dec 1, 2010·Journal of Bone and Mineral Metabolism·Junichi TakadaToshihiko Yamashita
Feb 2, 2011·Nature Reviews. Drug Discovery·Masanobu KawaiClifford J Rosen
Mar 12, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K RamamurthiK E Wilson
Jan 25, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Juliet E Compston, John P Bilezikian
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Mohammad Hassan MuradVictor M Montori
Jan 10, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven R CummingsE Michael Lewiecki
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneMichael P Whyte
Jun 29, 2013·Drug Design, Development and Therapy·Subhajit Das, Julie C Crockett
Jul 3, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D AnithaT Lee
Aug 21, 2013·SpringerPlus·Kazuhiro OhnaruMasao Fukunaga
Dec 19, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M ItoT Nakamura

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