Five-year follow-up after clinical islet transplantation

Diabetes
Edmond A RyanA M James Shapiro

Abstract

Islet transplantation can restore endogenous beta-cell function to subjects with type 1 diabetes. Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their mean age was 42.9 +/- 1.2 years, their mean duration of diabetes was 27.1 +/- 1.3 years, and 57% were women. The main indication was problematic hypoglycemia. Forty-four patients completed the islet transplant as defined by insulin independence, and three further patients received >16,000 islet equivalents (IE)/kg but remained on insulin and are deemed complete. Those who became insulin independent received a total of 799,912 +/- 30,220 IE (11,910 +/- 469 IE/kg). Five subjects became insulin independent after one transplant. Fifty-two patients had two transplants, and 11 subjects had three transplants. In the completed patients, 5-year follow-up reveals that the majority ( approximately 80%) have C-peptide present post-islet transplant, but only a minority ( approximately 10%) maintain insulin independence. The median duration of insulin independence was 15 months (interquartile range 6.2-25.5). The HbA(1c) (A1C) level was well controlled in those off insulin (6.4% [6.1-6.7]) and in those back on insulin but C-peptide positive (6.7% [5.9-7.5])...Continue Reading

References

Jul 1, 1990·Acta diabetologica latina·C RicordiR Alejandro
Jan 1, 1989·Diabetes·C RicordiD W Scharp
Jul 1, 1985·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Henderson, M C Moss
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J F TrotterG Everson
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Boaz HirshbergDavid M Harlan
Oct 22, 2003·Lancet·Hiroyuki SuminoMasahiko Kurabayashi
Oct 22, 2003·Lancet·A M James ShapiroBernhard Hering
Dec 5, 2003·Cell Transplantation·David A BaidalCamillo Ricordi
Feb 13, 2004·The New England Journal of Medicine·R Paul Robertson
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bernhard J HeringJeffrey A Bluestone
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·David E R SutherlandBernhard J Hering
Apr 17, 2004·Transplantation·Walid AboujaoudeMahendra V Govani
Oct 27, 2004·Transplantation·Marty T SellersDevin E Eckhoff
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Federico BertuzziAntonio Secchi
Nov 25, 2004·Metabolism: Clinical and Experimental·Olga VaccaroGabriele Riccardi
Dec 14, 2004·Transplantation·Pablo CureRodolfo Alejandro
Dec 24, 2004·Diabetes·Michael R RickelsKaren L Teff
Jan 25, 2005·Therapeutic Drug Monitoring·A M James ShapiroNorman M Kneteman
Jan 29, 2005·Diabetes Care·Edmond A RyanA M James Shapiro
Feb 17, 2005·JAMA : the Journal of the American Medical Association·Bernhard J HeringDavid E R Sutherland

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Citations

Dec 18, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Meng-Ju LiuHee-Sook Jun
May 24, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lu YangLiangyi Chen
Jun 20, 2006·Diabetologia·A N BalamuruganR Bottino
Nov 11, 2006·Diabetologia·M A LipsettL Rosenberg
Oct 16, 2009·World Journal of Surgery·Mark A HardyPaul Harris
Mar 30, 2007·Langenbeck's Archives of Surgery·Reinhard G BretzelMathias D Brendel
Jun 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hirofumi Noguchi, Shinichi Matsumoto
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Tetsuya IkemotoShinichi Matsumoto
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Hirohito Ichii, Camillo Ricordi
Mar 3, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiromi SasamotoShuhei Nakaji
Apr 11, 2009·Apoptosis : an International Journal on Programmed Cell Death·Aidan RyanFionnuala B Hickey
Sep 8, 2006·Digestive Diseases and Sciences·John I StagnerKaren Wyler
Dec 3, 2005·Pharmaceutical Research·Pleunie P M RoodMassimo Trucco
Aug 2, 2006·Current Diabetes Reports·Ziv NeemanBradford J Wood
Aug 2, 2006·Current Diabetes Reports·Emily C DyKristina I Rother
Aug 2, 2006·Current Diabetes Reports·Timothy C LeeJohn A Goss
Jul 18, 2008·Current Diabetes Reports·Cristiane B LeitãoRodolfo Alejandro
Jul 31, 2009·Current Diabetes Reports·Boaz Hirshberg
Sep 11, 2010·Current Diabetes Reports·Barbara LudwigStefan R Bornstein
Jul 13, 2011·Current Diabetes Reports·Roberto Bassi, Paolo Fiorina
Aug 2, 2011·Current Diabetes Reports·Marco MariglianoRita Bottino
Jul 15, 2011·Current Diabetes Reports·Carmen Fotino, Antonello Pileggi
Jul 30, 2011·Current Diabetes Reports·Sophie BorotThierry Berney
Aug 15, 2013·Current Diabetes Reports·J R F Abreu, B O Roep
Aug 21, 2013·Current Diabetes Reports·Sophie VériterDenis Dufrane
Aug 7, 2013·Current Diabetes Reports·Boris Gala-LopezA M James Shapiro
Aug 22, 2007·Cell Biochemistry and Biophysics·Nathalie Fiaschi-TaeschAdolfo Garcia-Ocaña
Aug 22, 2007·Cell Biochemistry and Biophysics·Prashanth VallabhajosyulaDavid H Sachs

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