Five year follow-up after primary vaccination against tick-borne encephalitis in children

Vaccine
Christoph WittermannElena Fragapane

Abstract

A first tick-borne encephalitis (TBE) vaccine booster in children is currently suggested 3 years after completing either a conventional (doses on Days 0, 28 and 300) or accelerated conventional (doses on Days 0, 14 and 300) TBE immunization schedule. This recommendation, however, may not be appropriate in cases where different TBE vaccines have been used interchangeably during the primary immunization series. To provide robust data to better inform such recommendations, TBE antibody persistence was evaluated after 3-5 years in four groups of children (aged 5-15 years): two groups previously primed with three doses of Encepur(®) Children (conventional/accelerated conventional schedule); and two groups previously primed with two doses of FSME-IMMUN(®) followed by a third dose of Encepur(®) Children (conventional/accelerated conventional schedule). Immunogenicity was evaluated using neutralization (NT) assays based on both vaccine antigens as well as on the Enzyme Linked Immunosorbent Assay (ELISA). In the two Encepur(®) Children groups (full series), protective NT titers of ≥10 were detected in 98-100% of children up to 5 years after their last primary vaccination, irrespective of schedule. In contrast, only 65-70% subjects in th...Continue Reading

References

Mar 10, 2006·International Journal of Medical Microbiology : IJMM·Pamela Rendi-WagnerHerwig Kollaritsch
Sep 23, 2006·Expert Review of Vaccines·Michael Bröker, Ines Schöndorf
May 4, 2010·Vaccine·Eva Maria PöllabauerHartmut J Ehrlich
Jun 13, 2012·Wiener medizinische Wochenschrift·Tomas Jelinek
Feb 5, 2013·Human Vaccines & Immunotherapeutics·Daniela AmiciziaRoberto Gasparini

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Citations

May 27, 2016·Der Nervenarzt·R Kaiser
Aug 2, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P TabaI Steiner
Apr 19, 2017·Emerging Infectious Diseases·Matthew H CollinsAravinda M de Silva
Mar 28, 2018·MMW Fortschritte der Medizin·René HandschuAlexander Schuh

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