Five-year follow-up of a randomized clinical trial of unilateral thyroid lobectomy with or without postoperative levothyroxine treatment.

World Journal of Surgery
Marcin BarczyńskiWojciech Nowak

Abstract

The aim of this study was to compare the prevalence of recurrent nodular goiter in the contralateral thyroid lobe among patients after unilateral thyroid lobectomy for unilateral multinodular goiter (MNG) receiving versus not receiving postoperative prophylactic levothyroxine (LT4) treatment. From January 2000 through December 2003, 150 consenting patients underwent a unilateral thyroid lobectomy for unilateral MNG at our institution. They were randomized to two groups with 75 patients in each group. Patients in group A received prophylactic LT4 treatment postoperatively (dose range 75-125 microg/day to maintain thyroid-stimulating hormone values below 1.0 mU/L), whereas patients in group B received no postoperative LT4 treatment. All the patients underwent ultrasonographic, cytologic, and biochemical follow-up for at least 60 months postoperatively. The primary outcome was the prevalence of recurrent goiter in the contralateral thyroid lobe. The secondary outcome was the reoperation rate for recurrent goiter. The outcomes were stratified according to individual iodine metabolism status assessed by urinary iodine excretion. During the 5-year follow-up, among patients receiving vs. not receiving LT4, recurrent goiter within the ...Continue Reading

References

Aug 1, 1986·World Journal of Surgery·P CheungJ Wong
Aug 1, 1974·The British Journal of Surgery·N J GriffithsD Burnett
Nov 1, 1984·Clinical Endocrinology·J P Geerdsen, L Frølund
Jun 1, 1996·World Journal of Surgery·C A SeilerH E Wagner
Mar 7, 1998·Annals of Internal Medicine·H Gharib, E L Mazzaferri
Aug 12, 1998·Journal of Endocrinological Investigation·P HarrerM Derwahl
Jan 28, 1999·Langenbeck's Archives of Surgery·P HarrerV Zumtobel
Feb 5, 1999·The Australian and New Zealand Journal of Surgery·C WadströmL Delbridge
Dec 5, 2002·The European Journal of Surgery = Acta Chirurgica·Maunzio MarchesiFrancesco P Campana
May 3, 2005·American Journal of Surgery·Hannah G PiperChristopher R Baliski
Sep 7, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew T SdanoDavid L Steward
Oct 21, 2006·The Journal of Laryngology and Otology·Y ErbilS Ozarmağan
Feb 20, 2007·World Journal of Surgery·Kylie L SnookLeigh Delbridge
Feb 16, 2008·The American Journal of Pathology·Anne-Catherine GérardFabrice Soncin
Mar 4, 2008·World Journal of Surgery·Roy Phitayakorn, Christopher R McHenry
May 14, 2008·Journal of Endocrinological Investigation·Z SzybinskiR Wasik

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Citations

Aug 3, 2011·Langenbeck's Archives of Surgery·F Hubertus Schmitz-WinnenthalMoritz von Frankenberg
Aug 29, 2013·World Journal of Surgery·Meena SaidPhilip I Haigh
Jun 20, 2013·The Journal of Surgical Research·Courtney J BalentineJames W Suliburk
Apr 24, 2016·Clinical Endocrinology·Maria LytriviBernard Corvilain
Jul 28, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Emilio García-GarcíaElena Navarro-González
Aug 3, 2018·Nature Reviews. Endocrinology·Livia LamartinaMartin Schlumberger
Dec 26, 2018·Annales d'endocrinologie·Marine Sarfati-LebretonStéphanie Mucci

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