Five-year follow-up of patients with benign prostatic hyperplasia treated with finasteride

European Urology
J Geller

Abstract

In 18 of 55 original patients who completed 5 years of treatment with finasteride, significant reductions in prostate size were noted at 1 year and sustained thereafter. Symptom scores in these same patients were significantly improved or stable over the 5 years while maximal urinary flow rates were unchanged. Data from 15 of 18 other patients who dropped out of the study before 5 years showed changes in prostate size, symptom score and flow rates that were similar to those noted in patients treated for 5 years. No side effects were noted in this study except for sexual dysfunction, which occurred in less than 5% of the patients. With few exceptions, finasteride appears to arrest the process of BPH over a 5 year period as indicated by sustained reductions in prostate size accompanied by either symptomatic improvement or stability in all other patients.

Citations

Dec 29, 2007·Pharmaceutical Development and Technology·Rajiv KumarOm Prakash Katare
Oct 12, 2010·The Cochrane Database of Systematic Reviews·James TacklindTimothy J Wilt
Aug 23, 2017·Expert Opinion on Emerging Drugs·Dominique ThomasAlexis Te
Apr 1, 1997·The Annals of Pharmacotherapy·M Lee, R Sharifi
Nov 24, 2012·Expert Opinion on Drug Safety·Serap GurWayne Jg Hellstrom
May 8, 2010·Expert Opinion on Emerging Drugs·Hashim Hashim, Paul Abrams

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