Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer.

The British Journal of Surgery
D G JayneP J Guillou

Abstract

The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open surgery for colorectal cancer. The results of the 5-year follow-up analysis are presented. Five-year outcomes were analysed and included overall and disease-free survival, and local, distant and wound/port-site recurrences. Two exploratory analyses were performed to evaluate the effect of age (70 years or less, or more than 70 years) on overall survival between the two groups, and the effect of the learning curve. No differences were found between laparoscopically assisted and open surgery in terms of overall survival, disease-free survival, and local and distant recurrence. Wound/port-site recurrence rates in the laparoscopic arm remained stable at 2.4 per cent. Conversion to open operation was associated with significantly worse overall but not disease-free survival, which was most marked in the early follow-up period. The effect of surgery did not differ between the age groups, and surgical experience did not impact on the 5-year results. The 5-year analyses confirm the oncological safety of laparoscopic surgery for both colonic and rectal cancer. The use of laparoscopic surgery to maxim...Continue Reading

References

Jan 1, 1997·International Journal of Colorectal Disease·S Tagliacozzo, A Tocchi
Mar 25, 2000·Diseases of the Colon and Rectum·L StocchiD M Ilstrup
Mar 3, 2001·Diseases of the Colon and Rectum·F MaruschUNKNOWN Laparoscopic Colorectal Surgery Study Group (LCSSG)
Jan 30, 2003·The British Journal of Surgery·M-C Le MoineJ Domergue
May 14, 2004·The New England Journal of Medicine·UNKNOWN Clinical Outcomes of Surgical Therapy Study GroupDavid Ota
Jun 26, 2004·Surgical Endoscopy·H MolooC M Schlachta
Sep 28, 2004·The British Journal of Surgery·N S AbrahamM J Solomon
Nov 13, 2004·Diseases of the Colon and Rectum·Sergio CasillasVictor W Fazio
Jul 5, 2005·The Lancet Oncology·Ruben VeldkampUNKNOWN COlon cancer Laparoscopic or Open Resection Study Group (COLOR)
Feb 2, 2006·Annals of Surgical Oncology·Omer AzizAlexander G Heriot
Jun 29, 2006·Aging Clinical and Experimental Research·Bo FengHong-Wei Li
Mar 21, 2007·Archives of Surgery·H Jacob BonjerUNKNOWN Transatlantic Laparoscopically Assisted vs Open Colectomy Trials Study Group
Apr 21, 2007·Digestive Surgery·Kiyotaka Okuno
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G JayneUNKNOWN UK MRC CLASICC Trial Group
Aug 19, 2007·The British Journal of Surgery·H ThorpeUNKNOWN Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer Trial Group
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas P WestPhilip Quirke
Nov 20, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W HohenbergerS Merkel

❮ Previous
Next ❯

Citations

Aug 24, 2011·International Journal of Colorectal Disease·Jimmy Chak-Man LiSophie Sok-Fei Hon
Nov 1, 2011·International Journal of Colorectal Disease·Ilmo KellokumpuKyösti Nuorva
Apr 2, 2011·Surgical Endoscopy·M Adamina, C P Delaney
Jun 28, 2011·Surgical Endoscopy·R SiegelUNKNOWN European Association for Endoscopic Surgery (EAES)
May 3, 2012·Surgical Endoscopy·Michel AdaminaConor P Delaney
Dec 15, 2012·Surgical Endoscopy·Marc ZereyUNKNOWN Members of the SAGES Guidelines Committee
Feb 9, 2013·Surgical Endoscopy·Andrew R DayTim A Rockall
Mar 20, 2013·Surgical Endoscopy·Kevin Kaity SngSeon-Hahn Kim
May 11, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroshi OhtaniKosei Hirakawa
Nov 29, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Helen M HeneghanJon D Vogel
Jul 6, 2013·Current Treatment Options in Oncology·Deborah Schrag
Jun 27, 2012·Nature Reviews. Gastroenterology & Hepatology·Josh WinerAmer H Zureikat
Oct 21, 2011·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Hubert ScheidbachHans Lippert
Mar 8, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Cem GezenMustafa Oncel
Jun 14, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Koo-Yong HahnSeon-Hahn Kim
Oct 23, 2012·British Medical Bulletin·J H Lai, W L Law
Jun 28, 2012·Annals of Surgery·Nikki E KolfschotenMichel W J M Wouters
Dec 8, 2011·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Cem GezenMustafa Oncel
Dec 8, 2011·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Masayuki NakashimaToshiharu Yamaguchi
Feb 10, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Zhenjie WuLu Wei
Apr 11, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Andrew DayTim Rockall
Jun 9, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Carrie Y PetersonSonia L Ramamoorthy
Apr 13, 2013·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Fumi HasegawaFumio Konishi
Oct 26, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A M WolthuisA D'Hoore
Nov 10, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M T JefferiesU Khot
Nov 30, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C W LaiM G Coleman
Feb 15, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S TrastulliC Boselli
May 1, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P MroczkowskiR Kube
May 9, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J P TiernanD G Jayne
Nov 30, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A BhanguP Tekkis

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