Five-year follow-up of the plaque sealing with paclitaxel-eluting stents vs medical therapy for the treatment of intermediate nonobstructive saphenous vein graft lesions (VELETI) trial

The Canadian Journal of Cardiology
Josep Rodés-CabauRobert DeLarochellière

Abstract

Very few data exist on the long-term follow-up of patients with intermediate nonobstructive saphenous vein graft (SVG) lesions. The purpose of this study was to evaluate the 5-year clinical outcomes of the patients enrolled in the Moderate Vein Graft Lesion Stenting With the Taxus Stent and Intravascular Ultrasound (VELETI) and the factors associated with SVG disease progression and outcomes. Patients with ≥ 1 intermediate SVG lesion (30%-60% diameter stenosis) were randomized to either stenting the SVG lesion with a paclitaxel-eluting stent (PES group, n = 30) or to medical treatment alone (MT group, n = 27). All patients were followed yearly up to 5 years. Major adverse cardiac events (MACEs) (cardiac death, myocardial infarction [MI], revascularization) related to the target SVG lesion tended to be lower in the PES group (17% vs 33%; P = 0.146) due to a lower lesion revascularization rate (13% vs 33%; P = 0.072), with no difference in cardiac death or MI between groups. MACEs related to the target SVG and global MACEs were similar between groups (P > 0.20 for both). A higher cholesterol level at baseline was the only independent predictive factor of MACEs related to the target SVG (P = 0.016). Over a 5-year period, one third...Continue Reading

Citations

Dec 6, 2014·Research in Cardiovascular Medicine·Luca Testa, Francesco Bedogni
Jan 26, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Nigussie BogaleAnthony Fung
Dec 17, 2014·Journal of the American College of Cardiology·Sanjay Kaul, Jagat Narula
Nov 7, 2016·Circulation. Cardiovascular Interventions·Josep Rodés-CabauUNKNOWN VELETI II Investigators (Sealing Moderate Coronary Saphenous Vein Graft Lesions With Paclitaxel-Eluting Stents)
Dec 6, 2019·Cardiology in Review·David Collins, Sheldon Goldberg

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