Five-year follow-up outcomes after Descemet's stripping automated endothelial keratoplasty: a retrospective study

BMJ Open Ophthalmology
Koichi WakimasuShigeru Kinoshita

Abstract

To assess graft survival and endothelial cell density (ECD) over a 5-year follow-up period after Descemet's stripping automated endothelial keratoplasty (DSAEK). This retrospective study involved 130 eyes of 130 consecutive patients with Fuchs endothelial corneal dystrophy (FECD), non-FECD bullous keratopathy (BK) (non-FECD) or BK post-trabeculectomy or tube-shunt surgery (glaucoma with bleb) who underwent DSAEK between August 2007 and January 2012 and were followed for more than 5 years postoperatively. Patients with previous keratoplasty, graft suture failure, primary graft failure, postoperative endophthalmitis and ocular infection were excluded. Graft survival and ECD was then examined in all patients who underwent DSAEK and completed the postoperative follow-up period. The association between clinical factors and 5-year graft survival after DSAEK was analysed with multivariate logistic regression analysis. The overall graft survival rate at 5 years postoperatively was 85%, yet significantly poorer in the glaucoma with bleb eyes (47%) than in the FECD (100%) or non-FECD (90%) eyes (p<0.01, log-rank test). In the FECD, non-FECD and glaucoma with bleb eyes, the mean ECD at 5 years postoperatively was 1054 cells/mm2, 1137 cell...Continue Reading

References

Nov 20, 1998·Cornea·G R MellesP S Binder
Nov 15, 2006·Cornea·Gerrit R J Melles
Nov 15, 2006·Cornea·Mark S Gorovoy
Apr 7, 2007·Cornea·Jun ShimazakiUNKNOWN Japan Bullous Keratopathy Study Group
Oct 14, 2011·Cornea·Arlene Ratanasit, Mark S Gorovoy
Apr 21, 2012·Survey of Ophthalmology·Arundhati AnshuFrancis W Price
Dec 18, 2016·Ophthalmology·Koji KitazawaShigeru Kinoshita
Jul 28, 2018·Cornea·Koji KitazawaShigeru Kinoshita

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