Five-year immunity persistence following immunization with inactivated enterovirus 71 type (EV71) vaccine in healthy children: A further observation

Human Vaccines & Immunotherapeutics
Yuemei HuFeng-Cai Zhu

Abstract

The longevity of antibodies induced by inactivated enterovirus 71 type (EV71) vaccine is not well studied. To estimate the immunity persistence following two-dose vaccination of EV71 vaccine, a five-year follow-up study was conducted as an extension of a Phase III clinical trial. In this study, a sub-cohort of volunteers who was eligible for enrollment and randomly administrated either 2 dose EV71 vaccine or placebo in the phase III clinical trial was selected, and then further observed 64 months post the 1st vaccination. 211 Subjects (106 vaccine subjects and 105 placebo subjects) who provided a full series of blood samples (at all the sampling points) were included in the final analyzed population. Seropositive rate (SR) and geometric mean titer (GMT) of the neutralizing antibodies (NAb) was calculated to detect the dynamic profiles of EV71 vaccine-induced immunogenicity. SR at the 5th year remained 94.34% in the vaccine subjects, with a GMT of 141.42. The SR was 71.43% in the placebo subjects, with a GMT of 71.83. Despite natural infection consistently promoted the NAb increase in the placebo subjects, the SR and GMT in vaccine subjects remained significantly higher than that in the placebo subjects at all the sampling point...Continue Reading

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Citations

Aug 2, 2019·Reviews in Medical Virology·Kam Leng Aw-YongYoke Fun Chan
Sep 5, 2019·Journal of Biomedical Science·Jing-Yi LinShin-Ru Shih
Jan 25, 2020·Human Vaccines & Immunotherapeutics·Shenyu WangHuakun Lv
Mar 7, 2021·Vaccines·Mei-Ling LiGary Brewer

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Datasets Mentioned

BETA
GU198367.1

Methods Mentioned

BETA
blood collection

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