PMID: 9427095Jan 14, 1998Paper

Five-year incidence and prediction of dementia and cognitive decline in a population sample of women aged 70-79 at baseline

International Journal of Geriatric Psychiatry
C BrayneC Gill

Abstract

To determine the incidence of dementia and cognitive decline and their predictors in a population sample. A rural geographically defined population served by a single health centre. 75% of the 70-74-year-old, 100% of the 75-79-year-old women registered with the practice. Interview the total sample using an augmented version of CAMDEX, including informant interview, and reaction times at baseline and 5 years later. IQ was estimated at baseline only. 365 women were interviewed at baseline, 237 at follow-up. Incidence of dementia of all severities was 3.1% per annum (95% CI, 2.2-4.3). CAMCOG declined by 12.6 points in those who became demented, MMSE by 3 points. Observed, self-reported and informant-reported cognitive difficulty at baseline all predicted later incidence of dementia. The additional use of estimated IQ and reaction times did not increase the efficiency of either cross-sectional detection of dementia or prediction of dementia at 5 years. The incidence of dementia was in the range reported by other studies; slight cognitive decline was noted in the total population, increasing with age and marked in incident dementia. Of clinical importance was the finding that both the individuals and the informants of those who subs...Continue Reading

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Citations

Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ha T NguyenKyriakos S Markides
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