Five-year local control in a phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer.

International Journal of Radiation Oncology, Biology, Physics
Gary M FreedmanLori J Goldstein

Abstract

Conventional radiation fractionation of 1.8-2 Gy per day for early stage breast cancer requires daily treatment for 6-7 weeks. We report the 5-year results of a phase II study of intensity modulated radiation therapy (IMRT), hypofractionation, and incorporated boost that shortened treatment time to 4 weeks. The study design was phase II with a planned accrual of 75 patients. Eligibility included patients aged≥18 years, Tis-T2, stage 0-II, and breast conservation. Photon IMRT and an incorporated boost was used, and the whole breast received 2.25 Gy per fraction for a total of 45 Gy, and the tumor bed received 2.8 Gy per fraction for a total of 56 Gy in 20 treatments over 4 weeks. Patients were followed every 6 months for 5 years. Seventy-five patients were treated from December 2003 to November 2005. The median follow-up was 69 months. Median age was 52 years (range, 31-81). Median tumor size was 1.4 cm (range, 0.1-3.5). Eighty percent of tumors were node negative; 93% of patients had negative margins, and 7% of patients had close (>0 and <2 mm) margins; 76% of cancers were invasive ductal type: 15% were ductal carcinoma in situ, 5% were lobular, and 4% were other histology types. Twenty-nine percent of patients 29% had grade 3 ...Continue Reading

References

Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RomestaingJ P Gérard
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·B FowbleP Anderson
May 7, 2002·Medical Physics·Chen-Shou ChuiBeryl McCormick
Aug 8, 2002·Journal of the National Cancer Institute·Timothy WhelanBarbara Szechtman
May 10, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John YarnoldRoger Owen
Jan 17, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ellen DonovanUNKNOWN Breast Technology Group
Mar 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Gary M FreedmanMonica Morrow
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia C FormentiKeith J DeWyngaert
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry BartelinkLaurence Collette
Feb 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Philippe PignolLawrence Paszat
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Gary M FreedmanPenny R Anderson

❮ Previous
Next ❯

Citations

Nov 3, 2012·Therapeutic Advances in Medical Oncology·Christos Markopoulos, Willemien van de Water
Jan 30, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·F SedlmayerUNKNOWN Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Dec 25, 2015·International Journal of Radiation Oncology, Biology, Physics·Stuti AhlawatAtif J Khan
Oct 12, 2015·Clinical Breast Cancer·Isabel LinaresRosario Del Moral
Jul 15, 2015·Radiation Oncology·Moamen M O M AlyYasser Abo-Madyan
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gary M FreedmanFrank A Vicini
Apr 27, 2016·The Breast : Official Journal of the European Society of Mastology·Daniel George HamiltonJason Wasiak
Mar 11, 2018·Journal of Applied Clinical Medical Physics·Huai-Wen ZhangYun-Lai Wang
Aug 13, 2014·World Journal of Clinical Oncology·Gokhan Ozyigit, Melis Gultekin
Aug 13, 2013·American Journal of Clinical Oncology·George KyrgiasVassilios Kouloulias
Nov 20, 2020·Breast Cancer : Targets and Therapy·Gabriella MacchiaAlessio G Morganti
Feb 5, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S DicuonzoB A Jereczek-Fossa
Aug 10, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·María Yicel Bautista HernandezAbril Antonia Quézada Bautista

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.