Five-year outcome of bipolar I and II disorders: findings of the Jorvi Bipolar Study

Bipolar Disorders
Sanna PallaskorpiErkki T Isometsä

Abstract

The long-term outcome of bipolar disorder (BD) has been extensively investigated. However, previous studies may be biased towards hospitalized patients with bipolar I disorder (BD-I), and generalizability to the current treatment era remains uncertain. In this naturalistic study, we followed a secondary-care cohort of patients with BD. In the Jorvi Bipolar Study, 191 patients with BD-I and bipolar II disorder (BD-II) were followed using a life-chart method. Interviews were conducted at six months, 18 months, and five years. Time to full remission, time to first recurrence, total time ill, their predictors, and BD-I versus BD-II differences were investigated among the 151 patients remaining in follow-up. Nearly all subjects recovered from the index episode, but almost all (90%) had a recurrence, and most had multiple recurrences. The patients spent about one-third of their time in illness episodes and 15% of their time with subthreshold symptoms; half of the time they were euthymic. After controlling for confounders, no difference in time spent in depressive states between patients with BD-I and BD-II persisted. Among patients with a depressive index phase, cluster C personality disorders [hazard ratio (HR) = 0.452, p = 0.040] a...Continue Reading

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Citations

Jan 13, 2018·Depression and Anxiety·Marco Antonio CaldieraroAndrew A Nierenberg
Jun 29, 2018·Psychological Medicine·Rudolf UherErkki Isometsä
Feb 13, 2019·Clinical Psychology & Psychotherapy·Helen WarwickWarren Mansell
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May 24, 2017·European Archives of Psychiatry and Clinical Neuroscience·Andrea MurruLudovic Samalin
Jan 12, 2019·Journal of Affective Disorders·Sanna PallaskorpiErkki Isometsä
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May 25, 2021·European Child & Adolescent Psychiatry·Diana KhoubaevaBenjamin I Goldstein
Feb 18, 2020·Psychiatry Research·Charles CotrenaRochele Paz Fonseca

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