Five-year outcomes from a prospective trial of image-guided accelerated hypofractionated proton therapy for prostate cancer

Acta Oncologica
Randal H HendersonNancy P Mendenhall

Abstract

To report 5-year outcomes of a prospective trial of image-guided accelerated hypofractionated proton therapy (AHPT) for prostate cancer. 215 prostate cancer patients accrued to a prospective institutional review board-approved trial of 70Gy(RBE) in 28 fractions for low-risk disease (n = 120) and 72.5Gy(RBE) in 29 fractions for intermediate-risk disease (n = 95). This trial excluded patients with prostate volumes of ≥60 cm3 or International Prostate Symptom Scores (IPSS) of ≥15, patients on anticoagulants or alpha-blockers, and patients in whom dose-constraint goals for organs at risk (OAR) could not be met. Toxicities were graded prospectively according to Common Terminology Criteria for Adverse Events (CTCAE), version 3.0. This trial can be found on ClinicalTrials.gov (NCT00693238). Median follow-up was 5.2 years. Five-year rates of freedom from biochemical and clinical disease progression were 95.9%, 98.3%, and 92.7% in the overall group and the low- and intermediate-risk subsets, respectively. Actuarial 5-year rates of late radiation-related CTCAE v3.0 grade 3 or higher gastrointestinal and urologic toxicities were 0.5% and 1.7%, respectively. Median IPSS before treatment and at 4+ years after treatment were 6 and 5 for low-...Continue Reading

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Citations

Mar 7, 2019·Cancer Investigation·R Charles NicholsNancy P Mendenhall
Jun 6, 2019·Journal of Applied Clinical Medical Physics·France CarrierJay Burmeister
Nov 28, 2019·International Journal of Particle Therapy·Jason M SlaterDavid A Bush
Jan 22, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Elisa ThomasMechthild Krause
Sep 6, 2019·Journal of Medical Imaging and Radiation Oncology·Jiří KubešKateřina Dědečková
Dec 14, 2018·Journal of Hematology & Oncology·Man HuJinming Yu
Oct 28, 2019·International Journal of Radiation Oncology, Biology, Physics·Thomas J Quinn, Daniel Hamstra
Feb 16, 2021·International Journal of Radiation Oncology, Biology, Physics·Jiří KubešJozef Rosina
Jun 15, 2019·International Journal of Radiation Oncology, Biology, Physics·Amardeep S GrewalNeha Vapiwala
Sep 25, 2021·The British Journal of Radiology·Yao-Yu Wu, Kang-Hsing Fan

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