Five-year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus.

Clinical & Experimental Ophthalmology
Jay J MeyerCharles N J McGhee

Abstract

Few studies have evaluated corneal crosslinking (CXL) in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of CXL to reduce the progression of keratoconus. Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre. Individuals with bilateral progressive keratoconus. One eye from each subject was randomised to CXL and the contralateral, untreated eye acted as the control. change in maximum keratometry. uncorrected distance visual acuity, spectacle corrected distance visual acuity, spherical equivalent refraction, simulated keratometry, corneal astigmatism, minimum pachymetry and complications. Thirty-eight individuals (mean age 21.1 ± 6.7 years) were enrolled with one eye treated with CXL. At 5 years, there was a mean decrease in maximum keratometry of treated eyes (-1.45 ± 2.25 D) compared to an increase among the controls (1.71 ± 2.46 D; p < 0.001). There were significant differences between the treated and control groups in the mean change of Steep SimK (-1.07 ± 1.22 vs. 0.96 ± 1.97 D; p < 0.001), Flat SimK (-0.61 ± 1.34 vs. 0.43 ± 1.12 D; p < 0.001), corneal astigmatism (-0.45 ± 1.31 vs. 0.63 ± 1.52 D; p < 0.01) and minimum pachymetry (-32.49 ± 26.32...Continue Reading

References

Sep 21, 2001·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·T W RaaschUNKNOWN CLEK Study Group. Collaborative Longitudinal Evaluation of Keratoconus Study
Jan 31, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G WollensakT Seiler
Apr 30, 2003·American Journal of Ophthalmology·Gregor WollensakTheo Seiler
Feb 22, 2005·Journal of Cataract and Refractive Surgery·Gerard Cairns, Charles N J McGhee
Nov 30, 2006·Cornea·Theo Seiler, Farhad Hafezi
Feb 27, 2007·Journal of Cataract and Refractive Surgery·Gregor WollensakChristopher Wirbelauer
Mar 3, 2009·Journal of Cataract and Refractive Surgery·Matthias Pollhammer, Claus Cursiefen
Mar 3, 2009·Journal of Cataract and Refractive Surgery·Romesh I AngunawelaBruce D S Allan
Jul 28, 2009·Journal of Cataract and Refractive Surgery·Tobias KollerTheo Seiler
Apr 19, 2011·Journal of Medical Case Reports·Georgios LabirisVassilios P Kozobolis
Jun 28, 2011·Journal of Cataract and Refractive Surgery·Steven A GreensteinPeter S Hersh
Jul 26, 2011·Journal of Cataract and Refractive Surgery·Tobias KollerTheo Seiler
May 26, 2015·Medical Archives·Sanja Sefic KasumovicMirko Jankov
Dec 15, 2015·The British Journal of Ophthalmology·Tom H FlynnMark R Wilkins
Mar 15, 2016·Eye and Vision·Joshua K DuncanMark Borgstrom
Aug 6, 2016·Journal of Cataract and Refractive Surgery·Bia Z KimDipika V Patel
Dec 21, 2016·American Journal of Ophthalmology·Jay J MeyerCharles N J McGhee
May 13, 2017·Ophthalmology·Peter S HershUNKNOWN United States Crosslinking Study Group

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Citations

Sep 5, 2021·The British Journal of Ophthalmology·Jay J MeyerCharles N J McGhee

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