Abstract
Background. Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by widespread nonfollicular sterile pustules. The aim of this study is to characterize the etiology, clinical features, laboratory findings, management, and outcome of patients with AGEP in Asians. Patient/Methods. A retrospective analysis was performed on patient who presented with AGEP between August 2008 and November 2012 in a tertiary center in Thailand. Results. Nineteen patients with AGEP were included. AGEP was generally distributed in seventeen patients (89.5%) and localized in two (10.5%). Fever and neutrophilia occurred in 52.6% and 68.4%, respectively. Hepatitis was found up to 26.3%. The most common etiology was drugs (94.7%), comprising of antibiotics (73.6%), proton pump inhibitors (10.5%), nonsteroidal anti-inflammatory drugs (5.3%), and herbal medicine (5.3%). Beta-lactams were the most common causal drug, particularly carbapenems and cephalosporins. This is the first report of Andrographis paniculata as an offending agent for AGEP. We found no differences between various treatment regimens (topical corticosteroid, systemic corticosteroid, and supportive treatment) regarding the time from drug cessation to p...Continue Reading
References
Sep 1, 1991·Archives of Dermatology·J C RoujeauL Vaillant
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Dec 29, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·S Malakar, S Dhar
Feb 13, 2001·Journal of Cutaneous Pathology·A SidoroffJ C Roujeau
Jul 20, 2002·Current Opinion in Allergy and Clinical Immunology·Markus Britschgi, Werner J Pichler
May 15, 2003·The Journal of Dermatological Treatment·V Mysore, A Ghuloom
Sep 15, 2007·The British Journal of Dermatology·A SidoroffJ-C Roujeau
Aug 19, 2008·Acta Dermato-venereologica·Shyue-Luen ChangHong-Shang Hong
Mar 6, 2009·International Journal of Dermatology·Elizabeth Guevara-GutierrezAlberto Tlacuilo-Parra
Jun 11, 2010·International Journal of Dermatology·Haur Yueh LeeT Thirumoorthy
Jun 15, 2010·European Journal of Dermatology : EJD·Marijn M SpeeckaertLieve Brochez
Jun 16, 2010·Annals of Dermatology·Min Jee ChoiYoung Min Park
Jun 24, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·R KabashimaY Tokura
Jul 28, 2011·Clinical and Experimental Dermatology·L DuckworthM A Thomson
Mar 1, 2012·Journal of Ethnopharmacology·Somtanuek ChotchoungchatchaiSompop Prathanturarug
Nov 10, 2012·The British Journal of Dermatology·A BarbaudUNKNOWN Toxidermies group of the French Society of Dermatology
Jul 17, 2013·The British Journal of Dermatology·C HotzO Chosidow
Sep 12, 2015·Journal of the American Academy of Dermatology·Jesse Szatkowski, Robert A Schwartz
Citations
Mar 4, 2017·The British Journal of Dermatology·N R AdlerE J Phillips
Jun 11, 2019·Case Reports in Dermatological Medicine·Aikaterini KyriakouElizabeth Lazaridou
Jun 3, 2020·Medicine·Kumpol Aiempanakit, Benjawan Apinantriyo
Aug 13, 2017·Drugs & Aging·James W S Young, Neil H Shear
Mar 23, 2018·Molecular Diagnosis & Therapy·Kalliopi GerogianniKonstantinos Dimas
May 6, 2019·Pediatric Dermatology·Andac SalmanEda Kepenekli Kadayifci
Jan 7, 2021·The American Journal of Dermatopathology·Enrico PezzarossaUNKNOWN CreSCO Study Group
May 27, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Nicolás Ariza OrdoñezJulian Mauricio Moreno
Aug 20, 2021·JAAD International·Dawn Ai Qun OhHaur Yueh Lee
Sep 15, 2020·Journal of the American Academy of Dermatology·Mohammad Amin HadavandJohn C L Trinidad