Five-Year Retrospective Review of Acute Generalized Exanthematous Pustulosis

Dermatology Research and Practice
Chitprapassorn ThienvibulKumutnart Chanprapaph

Abstract

Background. Acute generalized exanthematous pustulosis (AGEP) is an acute pustular eruption characterized by widespread nonfollicular sterile pustules. The aim of this study is to characterize the etiology, clinical features, laboratory findings, management, and outcome of patients with AGEP in Asians. Patient/Methods. A retrospective analysis was performed on patient who presented with AGEP between August 2008 and November 2012 in a tertiary center in Thailand. Results. Nineteen patients with AGEP were included. AGEP was generally distributed in seventeen patients (89.5%) and localized in two (10.5%). Fever and neutrophilia occurred in 52.6% and 68.4%, respectively. Hepatitis was found up to 26.3%. The most common etiology was drugs (94.7%), comprising of antibiotics (73.6%), proton pump inhibitors (10.5%), nonsteroidal anti-inflammatory drugs (5.3%), and herbal medicine (5.3%). Beta-lactams were the most common causal drug, particularly carbapenems and cephalosporins. This is the first report of Andrographis paniculata as an offending agent for AGEP. We found no differences between various treatment regimens (topical corticosteroid, systemic corticosteroid, and supportive treatment) regarding the time from drug cessation to p...Continue Reading

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Citations

Mar 4, 2017·The British Journal of Dermatology·N R AdlerE J Phillips
Jun 11, 2019·Case Reports in Dermatological Medicine·Aikaterini KyriakouElizabeth Lazaridou
Jun 3, 2020·Medicine·Kumpol Aiempanakit, Benjawan Apinantriyo
Aug 13, 2017·Drugs & Aging·James W S Young, Neil H Shear
Mar 23, 2018·Molecular Diagnosis & Therapy·Kalliopi GerogianniKonstantinos Dimas
Jan 7, 2021·The American Journal of Dermatopathology·Enrico PezzarossaUNKNOWN CreSCO Study Group
May 27, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Nicolás Ariza OrdoñezJulian Mauricio Moreno
Sep 15, 2020·Journal of the American Academy of Dermatology·Mohammad Amin HadavandJohn C L Trinidad

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
EuroSCAR

Related Concepts

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Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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