Five-year review of a UK 24 hour testing service for plasma ethylene glycol and diethylene glycol

Annals of Clinical Biochemistry
Loretta T Ford, Jonathan D Berg

Abstract

We present a 5-year review of our UK service for plasma ethylene glycol and diethylene glycol determination in cases of acute poisoning. Ethylene glycol and diethylene glycol have been measured on all samples received for screening for toxicity by gas chromatography-flame ionization detection over a five-year period. A detailed audit of the results has been undertaken. In this period, we received 811 requests, 56% were for first-time screening and 44% repeat analysis where a positive sample has already been received. Of the first-time screen samples, 33.5% screened positive for glycol poisoning. The mean positive ethylene glycol concentration was 1204 mg/L (range 31 to 8666 mg/L). Diethylene glycol was present in 14% of ethylene glycol positive samples but never found alone. The data presented here suggest it is not essential to measure diethylene glycol since its inclusion is rarely likely to change patient management.

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Citations

Sep 22, 2016·DNA Repair·Chao WangKanaga Sabapathy
Nov 4, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Neel PatelJ Allister Vale
Jan 12, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anneka VarmaJ Allister Vale
Jan 12, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Liam RobertsSally M Bradberry
Nov 5, 2016·Annals of Clinical Biochemistry·Arun SankaralingamAnthony S Wierzbicki
Mar 8, 2019·Drug Testing and Analysis·Daniel Sejer PedersenTorben Breindahl

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