Five-year survival after cryoablation of stage I non-small cell lung cancer in medically inoperable patients

Journal of Vascular and Interventional Radiology : JVIR
William MooreThomas Bilfinger

Abstract

To evaluate retrospectively the long-term survival of patients with early-stage non-small cell lung cancer (NSCLC) treated with cryoablation. Cryoablation was performed on 47 T1N0M0 NSCLCs in 45 consecutive patients between 2006 and January 2011. All ablative procedures were performed with 16-gauge or 13-gauge cryoprobes. The number of probes used was determined by the size and geometry of the tumor. Local and regional recurrence rates were monitored. Complications were assessed by the Society of Interventional Radiology (SIR) classification system. The 5-year survival rate was 67.8% ± 15.3, the cancer-specific survival rate at 5 years was 56.6% ± 16.5, and the 5-year progression-free survival rate was 87.9% ± 9. The probe per unit tumor diameter was 1.4 probes/cm. In eight patients, 16-gauge cryoprobes were used. Two cases were performed with a single needle. The remaining cases were performed with 13-gauge cryoprobes except for one case in which both probe sizes were used. The combined local and regional recurrence rate was 36.2%. Major complications occurred in 6.4% of patients, including two cases of hemoptysis and a prolonged placement of a chest tube requiring mechanical sclerosis in one patient. There were no deaths in t...Continue Reading

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