Five-year survival does not equal cure in non-small cell lung cancer: a Surveillance, Epidemiology, and End Results-based analysis of variables affecting 10- to 18-year survival

The Journal of Thoracic and Cardiovascular Surgery
Matthew O HubbardPhilip A Linden

Abstract

Five-year survival after the diagnosis of non-small cell lung cancer is the most common benchmark used to evaluate long-term survival. Data on survival beyond 5 years are sparse. We sought to elucidate variables affecting 10- to 18-year survival. A total of 31,206 patients alive at least 5 years after diagnosis of non-small cell lung cancer who were registered in the Surveillance, Epidemiology, and End Results database from 1988 to 2001 were examined. Primary end points were disease-specific survival and overall survival. Survival analysis was performed with Kaplan-Meier estimates, multivariable Cox proportional hazards regression, and competing risk models. Overall survival at 10, 15, and 18 years was 55.4%, 33.1%, and 24.3%, respectively. Disease-specific survival at 10, 15, and 18 years was 76.6%, 65.4%, and 59.4%, respectively. In multivariable regression analysis, squamous cell cancers had a disease-specific survival advantage (hazard ratio, 0.88; P < .0001) but an overall survival disadvantage (hazard ratio, 1.082; P = .0002) compared with adenocarcinoma. Pneumonectomy (hazard ratio, 0.44) and lobectomy (hazard ratio, 0.474) had improved disease-specific survival compared with no surgery (P < .0001). Left-sided tumors (ha...Continue Reading

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Citations

Apr 27, 2013·Journal of Cardiothoracic Surgery·Kazuto OhtakaYoshiro Matsui
Nov 7, 2015·The Annals of Thoracic Surgery·Ken KodamaKeiko Kuriyama
Aug 29, 2012·The Journal of Thoracic and Cardiovascular Surgery·Duha FahhamOri Wald
Feb 13, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L G Janssen-HeijnenH J M Groen
Jun 9, 2016·Chemico-biological Interactions·Boondaree Siriwarin, Natthida Weerapreeyakul
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sashendra Senthi, Suresh Senan
Apr 14, 2017·Current Opinion in Pulmonary Medicine·Ching-Fei Chang, Michael Gould
Jun 18, 2017·Expert Review of Anticancer Therapy·Omar Abdel-Rahman
Aug 2, 2020·International Journal of Cancer. Journal International Du Cancer·Jung Eun YooKyu-Won Jung
Apr 21, 2017·Current Medical Research and Opinion·Omar Abdel-Rahman
Apr 5, 2020·Cancers·Joerg LindenmannFreyja Maria Smolle-Juettner
Jan 16, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hossein BorghaeiJulie Brahmer

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