PMID: 4899454Nov 1, 1969Paper

Five-year winter chemoprophylaxis for chronic bronchitis

British Medical Journal
R N JohnstonF G Ward

Abstract

Seventy-nine patients with chronic bronchitis were randomly allotted to four treatment regimens-placebo throughout the winter months for five years; tetracycline for the first two winters and placebo for the next three; placebo for the first two winters and tetracycline for the next three; and tetracycline for five winters. In addition all groups recevied a five-day course of tetracycline for any acute exacerbation. There was a significant reduction in the number of exacerbations among the more susceptible patients-that is, those who suffered more than one exacerbation each winter. Though the average decline in F.E.V.(1) over the five-year period was less in the treated groups this was not statistically significant. There was no significant difference between the groups in respect of lung volumes, diffusing capacity, and blood gases.

Citations

Mar 13, 1975·The New England Journal of Medicine·I Tager, F E Speizer
Jul 1, 1972·Antimicrobial Agents and Chemotherapy·H H HahnH N Beaty
Feb 4, 1984·British Medical Journal·R Cutler
Sep 1, 1976·Postgraduate Medical Journal·J Batten
Mar 4, 2003·Thorax·W MacNee, P M A Calverley
Feb 1, 1976·Thorax·R N JohnstonF Fletcher
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·W MacNee
Oct 1, 1992·The American Review of Respiratory Disease·T F Murphy, S Sethi
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Nov 22, 2008·American Journal of Respiratory and Critical Care Medicine·Ken M Kunisaki, Dennis E Niewoehner
Feb 16, 2010·Expert Opinion on Investigational Drugs·D M MurphyC Ward
Jul 1, 1978·British Journal of Diseases of the Chest·D Davies, C S Darke
Apr 1, 1972·British Journal of Diseases of the Chest·A PinesM E Solari
Nov 30, 2013·The Cochrane Database of Systematic Reviews·Samantha C Herath, Phillippa Poole
Dec 3, 2013·The Cochrane Database of Systematic Reviews·Toni StaykovaPhillippa Poole
Feb 24, 2001·Biological & Pharmaceutical Bulletin·J TanakaT Yamakawa
Mar 2, 2006·Biological & Pharmaceutical Bulletin·Yu-Ming ChiShinobu Sakurada
Jun 13, 1975·Annals of the New York Academy of Sciences·A L Oronsky, R J Perper
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·U E Nydegger, J S Davis
Jun 3, 2020·Journal of Clinical Medicine·José Luis Lopez-CamposMiguel Angel Martinez-Garcia
Dec 13, 2016·Pharmaceutical Biology·Ana Claudia Hertel PereiraDenise Coutinho Endringer
Apr 1, 1979·Scottish Medical Journal·J A Gray
Apr 1, 1984·Drug Intelligence & Clinical Pharmacy·M R AlexanderA L Mustion
Oct 31, 2018·The Cochrane Database of Systematic Reviews·Samantha C HerathPhillippa Poole

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