PMID: 332115Jul 19, 1977Paper

Fixation-induced cyst-like spaced in the brains of rabbit foetuses

Archives of Toxicology
A NiggeschulzeJ Notman

Abstract

During teratologic trials, routine investigations of 4261 brains from rabbit foetuses, fixed in Bouin's solution and sectioned by Wilson's free-hand razor blade technique, revealed cyst-like spaces in the brains of 164 foetuses (3.8%). The cyst-like spaces, characterised by the absence of an epithelial or endothelial lining, were usually solitary and occurred mainly in the massa intermedia of the thalamus. The spaces were found almost as ofter in control foetuses as in those from treated animals. On the basis of histologic examination and different fixation techniques, involving a further 1430 foetuses, these cyst-like spaces, previously interpreted as strain specific brain malformations, can be regarded as fixation artefacts.

References

Feb 1, 1976·Toxicology and Applied Pharmacology·G M SzczechR G Carlson
Oct 3, 1973·Histochemie. Histochemistry. Histochimie·N I GerminoM A Castellano
Apr 1, 1973·Teratology·D B ShurtleffJ A Oakland
Jan 1, 1972·Biology of the Neonate·J C Larroche
Jan 1, 1971·Toxicology and Applied Pharmacology·H Lehmann, A Niggeschulze

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Citations

Jun 13, 2008·Cell and Tissue Banking·Lea T GrinbergUNKNOWN Brazilian Aging Brain Study Group
Sep 23, 2008·Reproductive Toxicology·Julian FrenchJane Stewart
Feb 24, 2015·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mary K ZiejewskiDinesh Stanislaus

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