Fixation of bioprosthetic tissues with monofunctional and multifunctional polyepoxy compounds

Journal of Biomedical Materials Research
R TuR C Quijano


Collagen from a native tissue is fixed with a polyepoxy compound (PC) for use as a new biologic prosthetic material. Prior studies have shown that this biomaterial has comparable properties with collagen fixed with glutaraldehyde (GA), and thus has great promise for biomedical applications. A prior kinetic study indicated that the reaction between the functional groups of collagen and the multifunctional epoxy EX-313 is a 2.5th-order reaction. The purpose of this study was to understand the mechanism of the amino acid-PC reactions in a fixation process. Bovine arteries were fixed with a monofunctional PC (EX-131) and a multifunctional PC (EX-313) as a function of fixation time. A sequential fixation with a second fixative was used to identify the available remaining reactive sites from a prior fixation. The denaturation temperature (Td) was measured on each sample. Because the denaturation temperature is a direct indication of crosslinking of individual amino acids with the fixative, the increase in Td of a subsequent fixation may be indicative of the available remaining amino acids. The fixation index was measured on each sample to reflect the increase of fixation completion in a sequential fixation process. The fixation index...Continue Reading


Mar 1, 1976·Annals of Surgery·H Dardik, I I Dardik
Jan 1, 1984·Annual Review of Biochemistry·D R EyreP M Gallop
Jan 1, 1993·Journal of Biomedical Materials Research·R TuR C Quijano

❮ Previous
Next ❯


Jan 1, 1996·Journal of Biomedical Materials Research·H W SungS A Liu
Nov 25, 1998·Journal of Biomedical Materials Research·H W SungC T Chiu
Jul 9, 1999·Journal of Biomedical Materials Research·R ZeemanJ Feijen
Aug 17, 1999·Journal of Biomedical Materials Research·P B van WachemM J van Luyn
Jun 29, 2007·Journal of Materials Science. Materials in Medicine·Xi-xun YuHuai-qing Chen
Apr 1, 1996·Biomaterials·L H Olde DaminkJ Feijen
Jun 7, 2000·Journal of Biomaterials Science. Polymer Edition·A J KuijpersJ Feijen
Jan 10, 2003·Journal of Biomaterials Science. Polymer Edition·Kezban UlubayramNesrin Hasirci
Jan 1, 1997·Journal of Biomaterials Science. Polymer Edition·H W SungH L Hsu
Aug 12, 2015·International Journal of Molecular Sciences·Long XuChun Ye
Mar 11, 2008·Biochimica Et Biophysica Acta·N A DanilovV V Lunin
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Veronika ŠvachováJosef Jančář
Jun 17, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·W M L NeethlingR Glancy
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paul F GratzerJ Michael Lee
May 29, 2007·Journal of Biomedical Materials Research. Part a·Fwu-Long MiHsing-Wen Sung
Jan 1, 1997·Artificial Organs·H W SungP C Yang
May 26, 1999·Journal of Biomaterials Applications·J M García Páez, E Jorge-Herrero
Mar 10, 1998·Journal of Biomedical Materials Research·L L HuangK H Hsieh
May 1, 1997·Journal of Biomedical Materials Research·H W SungH L Hsu
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Irina Yu ZhuravlevaBoris A Trofimov
Apr 13, 2021·Chemical Reviews·Xuanhe ZhaoGerman Parada
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Sep 17, 2009·Bioconjugate Chemistry·Benedict Law, Ching-Hsuan Tung

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.