PMID: 15335000Sep 1, 2004Paper

Fixation of distal femoral osteotomies with self-reinforced poly(L/DL)lactide 70:30/bioactive glass composite rods. An experimental study on rats

Journal of Materials Science. Materials in Medicine
Pyhältö TuomoTörmälä Pertti

Abstract

Self-reinforced poly(L/DL)lactide 70:30/bioactive glass [SR-P(L/DL)LA/bioactive glass] composite rods, 2 mm in diameter and 36 mm in length, were implanted into the dorsal subcutaneous tissue of 16 rats. Osteotomies of the distal femur were fixed with these rods (2 x 15 mm) in 64 other rats. The follow-up times varied from one week to one year. After sacrifice, three-point bending and shear tests, and molecular weight measurements were performed for subcutaneously placed rods. Radiological, histological, histomorphometrical, microradiographic, and oxytetracycline-fluorescence studies of the osteotomized and intact control femora were performed. At 24 weeks the mechanical properties had decreased significantly. Thirty-nine osteotomies healed uneventfully. One of the 64 evaluated osteotomies showed signs of infection at six weeks, and there were 19 non-unions and six delayed unions. In 20 operations the fixation was loose and out of these 14 non-unions were observed. No gross signs of inflammatory or foreign-body reactions were observed. The present investigation showed that the mechanical strength and fixation properties of SR-P(L/DL)LA/bioactive glass composite rods are suitable for fixation of cancellous bone osteotomies in ra...Continue Reading

Citations

Feb 18, 2010·Journal of Materials Science. Materials in Medicine·Hanna TölliPekka Jalovaara
Jul 13, 2011·International Journal of Molecular Sciences·Tommaso CasaliniGiuseppe Perale
Feb 14, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gwenaelle VergnolDaniel J Hartmann
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Saeid Tajbakhsh, Faezeh Hajiali
Nov 18, 2005·Expert Review of Medical Devices·Aldo R Boccaccini, Jonny J Blaker

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