Fixation, retention and exhalation of carrier-free 11C-labeled carbon monoxide by man

Radiation and Environmental Biophysics
R WeinreichG Stöcklin

Abstract

Carrier-free 11C-labeled carbon monoxide was produced by proton irradiation of a nitrogen gas flow target via the 14N(p, alpha)11C process followed by on-line reduction of the predominantly formed 11C-carbon dioxide with a yield of 0.4 mCi/muAmin. After appropriate quality control about 2 mCi of carrier-free 11C-carbon monoxide in 500 ml on nitrogen gas were inhaled by test subjects in one breath. The 11C-activity distribution was then followed in vivo by scanning above thorax, head, liver, thigh and os sacrum; simultaneously the 11c-activity of the blood was also followed by batch measurement. The data indicate that part of the 11C-activity migrates from the blood into the intercellular space, while another part is exhaled. The 11C-activity leaves the individual organs with a biological half-life ranging from about 120 to 200 min, a time which is short as compared to the one observed for 51Cr-labeled erythrocytes. A radio gas chromatographic analysis of the exhaled air showed that the 11C-activity leaves the body exculsively in the form of 11C-labeled carbon monoxide. Consequently, metabolism of the 11CO into 11CO2 or other compounds can be excluded.

References

Nov 1, 1971·The International Journal of Applied Radiation and Isotopes·J C Clark, P D Buckingham
Jan 1, 1969·Journal of Applied Physiology·H I GlassJ C Clark
Oct 1, 1963·The International Journal of Applied Radiation and Isotopes·P D BUCKINGHAM, G R FORSE
Dec 1, 1945·The American Journal of Physiology·C A TOBIAS, J H LAWRENCE

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Citations

Dec 1, 1978·Toxicology and Applied Pharmacology·M S RaybournC A Tobias

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