PMID: 718320Nov 1, 1978

Fixed-bed charcoal hemoperfusion. Treatment of drug overdose

Archives of Internal Medicine
A KofflerS G Massry

Abstract

Fixed-bed activated charcoal cartridges were used for hemoperfusion in the treatment of 54 patients with overdose of one or more drugs, including barbiturate, glutethimide, ethchloryvnol, meprobamate, methyprylon, methaqualone, salicylate, and diazepam. The most dramatic improvement was noticed in patients with phenobarbitol intoxication; they were admitted in stage 3-4 coma and were either awake or arousable by verbal communication at the end of 1 1/2 to 3 1/2 hours of hemoperfusion. Other intoxications improved slowly and required longer duration of treatment. The clearance rates of the drugs with hemoperfusion were greater than those usually achieved with hemodialysis. The data demonstrate the efficacy and usefulness of charcoal hemoperfusion for the management of drug overdose.

Citations

May 1, 1983·Artificial Organs·S C KathpaliaV S Lim
Jul 7, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert MactierEXTRIP Workgroup
May 1, 1990·The American Journal of Emergency Medicine·R P Yell
Jan 1, 1985·The Journal of Emergency Medicine·R H Dailey
Jan 1, 1981·Annals of Emergency Medicine·A R Soslow
Feb 4, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Darren M Roberts, Nick A Buckley
Jan 1, 1981·Clinical and Experimental Dialysis and Apheresis·S B SmithR Venkatesan
May 20, 2015·Annals of Emergency Medicine·David N JuurlinkEXTRIP Workgroup
Feb 26, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wee-Keat CheahFei-Yee Yeoh

Related Concepts

Barbiturates
Calcium
Actidose
Placidyl
Noxiron
Hemoperfusion
Luminal
Red Phosphorus
Poisoning

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