Fixed-Dose combination of the inhaled corticosteroid and long-acting beta2-agonist therapy in adults with persistent asthma

Expert Opinion on Pharmacotherapy
Hiroshi Chantaphakul, Kiat Ruxrungtham

Abstract

Asthma is a respiratory condition characterized by airway inflammation, airflow obstruction, and bronchial hyperresponsiveness. The standard treatment of asthma comprises inhaled corticosteroid and beta2-agonist. Inhaled short-acting-beta2-agonists have been used as rescue medication for exacerbation. However, long-acting-beta2-agonists (LABA) used as monotherapy for asthma had been reported for having a safety concern. Consequently, it had been recommended as an add-on treatment to inhaled corticosteroid (ICS) in moderate to severe persistent asthma. The fixed-dose combination (FDC) of ICS and LABA has been approved since the year 2000. Evidences revealed using the combination of these medications is more effective in asthma control. The rational and phase III onward randomized-controlled studies were reviewed. Sources of evidences were from studies published in Medline until November 2015. There are six FDC inhaler regimens approved worldwide. The significant synergistic effects of ICS and LABA in one device are well evidenced. A FDC reduces the daily dosage of ICS and asthma exacerbation. It is safe to use regularly as controller. The efficacy of each individual combination on asthma treatment is generally similar. Clinical ...Continue Reading

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Citations

Mar 13, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Shiyuan ZhangAfisi S Ismaila
Oct 31, 2020·Pharmacology & Therapeutics·Farah ElawarDavid J Marchant
Jul 3, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Devaveena DeyThomas A Davis

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