PMID: 9427169Jan 14, 1998Paper

Fixed drug eruption caused by tosufloxacin tosilate

The Journal of International Medical Research
S Nishijima, M Nakagawa

Abstract

A 39-year-old woman presented with a purple-red macula, 2 cm in diameter, on the back of her right hand. She had had similar maculae at this location several times before and residual pigmentation had persisted for 6 months. Histopathological examination showed slight acanthosis of the epidermis and perivascular round-cell infiltration and melanophages in the dermis. Oral provocation tests with five drugs that the patient had received as common-cold treatments on different occasions were positive only in the case of tosufloxacin; after an hour the skin lesion reappeared. To our knowledge this is the first published report of a fixed drug eruption caused by tosufloxacin, although such eruptions have previously been reported for several other fluoroquinolones.

References

Feb 1, 1979·The British Journal of Dermatology·J S Pasricha
Nov 1, 1974·The British Journal of Dermatology·C A Ramsay, E Obreshkova
Sep 1, 1994·Contact Dermatitis·A KawadaH Banba

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Citations

Aug 17, 2006·International Journal of Dermatology·Virendra N Sehgal, Govind Srivastava
Jul 29, 2017·Current Allergy and Asthma Reports·Inmaculada DoñaMaría José Torres

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