FK 506 for liver, kidney, and pancreas transplantation.

Lancet
T E StarzlA Jain

Abstract

FK 506 was given for immunosuppression in 14 liver recipients. The drug was used in the first 10 cases because the recipients under conventional immunosuppression had rejection, nephrotoxicity, or both. This salvage therapy was successful in 7 of the 10 attempts. 2 of the 10 patients in the original salvage group as well as 4 new patients underwent fresh orthotopic liver transplantation under FK 506 plus low-dose steroids from the outset. None of these 6 patients had rejection although 1 with preexisting cor pulmonale and coronary atherosclerosis died of a myocardial infarction. In addition, 2 of the 14 liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor. There were no rejections of the kidney and pancreas grafts, and serious side-effects were not encountered.

Citations

Jun 1, 1992·Archives of Dermatology·B V JegasothyT E Starzl
May 16, 1990·JAMA : the Journal of the American Medical Association·T E Starzl, J J Fung
Jul 4, 1990·JAMA : the Journal of the American Medical Association·T E StarzlM Alessiani
Mar 15, 1995·JAMA : the Journal of the American Medical Association·T E Starzl, A J Demetris
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B EghtesadT E Starzl
Jul 1, 1993·Journal of Clinical Pharmacology·A B JainR Venkataramanan
Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P Y WongR Williams
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T E Starzl
Mar 10, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A B JainJ J Fung
Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K Wenzel-Seifert, R Seifert
Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·S V McDiarmidR W Busuttil
Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·M WinklerR Pichlmayr
Aug 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·M WinklerR Pichlmayr
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·S JonasP Neuhaus
Jan 1, 1995·Archives of Dermatological Research·F FurukawaM Takigawa
Oct 1, 1991·Calcified Tissue International·S Epstein
Feb 11, 1998·Molecular Neurobiology·B G Gold
Jun 1, 2000·World Journal of Surgery·T E Starzl
Dec 19, 2007·Medical Microbiology and Immunology·Monto Ho
Nov 4, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tania ClaeysRita Van Damme-Lombaerts
Mar 27, 2007·Cell Biology and Toxicology·T TakaderaT Ohyashiki
Oct 1, 2013·Cell Biology and Toxicology·María PalacínEduardo Ruiz-Pesini
Sep 17, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ruy J CruzKareem M Abu-Elmagd
Sep 12, 2000·Current Gastroenterology Reports·A UklejaJ S Scolapio
Aug 1, 1994·The Annals of Thoracic Surgery·T HiraiA S Slutsky
Sep 1, 1995·The Annals of Thoracic Surgery·R J KeenanB P Griffith
Sep 1, 1995·The Annals of Thoracic Surgery·R M Bolman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.