FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3

Kidney International
Yohei IkezumiHiroshi Kawachi

Abstract

We have previously reported that CD4 T lymphocytes and their cytokines contribute to development of Thy 1.1 glomerulonephritis (GN). FK506 is reported to suppress the production of Th1 cytokines. The aims of this study were to elucidate the role of Th1 cytokines on mesangial alteration and to examine whether FK506 is available for therapy of mesangial proliferative GN. The effects of daily treatments of FK506 from day -5 and from day +1 of Thy 1.1 GN induction on glomerular alterations were analyzed. FK506 treatment with 1.0 and 0.3 mg/kg body weight (BW) daily from day 1 to day 4 significantly reduced the glomerular expression of mRNA for interferon-gamma (IFN-gamma; 1.0 mg/kg BW FK506, 32.4% to the placebo group, P < 0.01) and IL-2 (55.6%, P < 0.01) on day 5. FK506 treatment from day -5 of GN induction reduced proteinuria and glomerular alteration in a dose-dependent manner. Although no side effects were detected in rats with 0.3 mg/kg BW of FK506 treatment from day +1, the treatment also ameliorated proteinuria (day 14, 3.7 +/- 0.89 vs. 19.8 +/- 12.3 mg/100 g BW/day P < 0.05) and glomerular alterations [total cell number, 63.1 +/- 3.1 vs. 80.2 +/- 7.4, P < 0.01; matrix expansion, 0.90 +/- 0.30 vs. 1.34 +/- 0.27, P < 0.05; al...Continue Reading

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Citations

Aug 26, 2004·Kidney International·Yohei IkezumiHiroshi Kawachi
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaki AsaiTakao Saruta
Apr 11, 2008·Journal of the American Society of Nephrology : JASN·Roland VeelkenGisa Tiegs
Jan 22, 2005·Journal of Hypertension·Piet FinckenbergEero M A Mervaala
Sep 24, 2008·Biochemical and Biophysical Research Communications·Yohei IkezumiMakoto Uchiyama
Jan 14, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Cecilia M ShingJeff S Coombes
Feb 14, 2006·The Journal of Investigative Dermatology·Karin LoserStefan Beissert
Sep 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chi Chiu Mok
Oct 7, 2017·Journal of the American Society of Nephrology : JASN·Isabelle Ayoub, Brad H Rovin
Aug 8, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Junya YamahanaShuichi Kaneko
Feb 7, 2015·American Journal of Physiology. Renal Physiology·Yoshiki HigashijimaMasaomi Nangaku
Dec 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jing ZhangYingwei Wang
May 21, 2020·Frontiers in Cell and Developmental Biology·María José Ramírez-BajoFritz Diekmann
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Gi Dong HanHiroshi Kawachi
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Chi Chiu Mok

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