PMID: 8588226Dec 1, 1995Paper

FK506 in solid organ transplantation

Therapeutic Drug Monitoring
J J Fung, T E Starzl

Abstract

FK506 (Prograf) is a new immunosuppressive agent, recently approved for use in solid organ transplants. The first use of FK506 was for the indication of refractory liver allograft rejection. This revealed a marked ability to reverse ongoing rejection, even in cases where chronic changes were observed. Between 50 and 70% of patients converted to FK506 had shown improvement. In long-term follow-up of patients with chronic rejection, 75% of patients were still alive at 3 years following FK506 conversion, and 65% of liver allografts were still functioning. FK506 has been compared to cyclosporine in primary liver transplantation. In the three randomized trials, freedom from rejection was statistically greater in the FK506-treated group, as compared to the cyclosporine-treated group. By intent-to-treat analysis, the patient and graft survival in the FK506 group was the same or better than the cyclosporine group. The good results in the cyclosporine limb was due, in part, to the ability of FK506 to treat rejection in the cyclosporine group. Freedom from steroid use, and the lower incidence of hypertension, were prominent features of FK506 patients. FK506 has been used for rescue of rejecting kidney allografts, with results similar to ...Continue Reading

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Citations

Nov 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A Klein
Sep 2, 1998·Transplantation Proceedings·A Cheung, A H Menkis
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Mar 25, 2014·Journal of Molecular Graphics & Modelling·Lilian Olivieri, Fabrice Gardebien
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mark S RobertsLisa Weissfeld
Oct 16, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Davide MineoCamillo Ricordi
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brett GlotzbeckerRobert Soiffer
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Oct 13, 2020·Frontiers in Immunology·Dimitrios GiannisLinda C Cendales
Mar 8, 2011·Journal of Chemical Theory and Computation·Lilian Olivieri, Fabrice Gardebien

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