FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins

Brain Imaging and Behavior
Aldo Córdova-PalomeraLourdes Fañanás

Abstract

The hippocampus is a key modulator of stress responses underlying depressive behavior. While FKBP5 has been found associated with a large number of stress-related outcomes and hippocampal features, its potential role in modifying the hippocampal communication transfer mechanisms with other brain regions remains largely unexplored. The putative genetic or environmental roots of the association between depression and structural connectivity alterations of the hippocampus were evaluated combining diffusion weighted imaging with both a quantitative genetics approach and molecular information on the rs1360780 single nucleotide polymorphism, in a sample of 54 informative monozygotic twins (27 pairs). Three main results were derived from the present analyses. First, graph-theoretical measures of hippocampal connectivity were altered in depression. Specifically, decreased connectivity strength and increased network centrality of the right hippocampus were found in depressed individuals. Second, these hippocampal alterations are potentially driven by familial factors (genes plus shared environment). Third, there is an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectiv...Continue Reading

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Citations

Dec 6, 2017·International Journal of Molecular Sciences·Gabriel R FriesTheo Rein
Feb 19, 2020·Neuroscience and Biobehavioral Reviews·Helena Palma-GudielLourdes Fañanás
Apr 3, 2021·Journal of Affective Disorders·Charlene N Rivera-BonetHeather C Abercrombie
May 10, 2019·Neuropsychobiology·Marco CalabròAlessandro Serretti

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Methods Mentioned

BETA
genotyping

Software Mentioned

MATLAB
R
FreeSurfer
Brain Connectivity Toolbox
rms package

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