PMID: 11335139May 4, 2001Paper

Flagellin expressed by live Salmonella vaccine strains induces distinct antibody responses following delivery via systemic or mucosal immunization routes

FEMS Immunology and Medical Microbiology
M E Sbrogio-Almeida, L C Ferreira

Abstract

Salmonella flagellin, expressed as flagella in live attenuated vaccine strains, elicits distinct systemic (IgG) and secreted (IgA) antibody responses in mice following delivery via mucosal (nasal/oral) or parenteral (intraperitoneal (i.p.)) immunization routes. Reduced flagellin-specific antibodies were detected either systemically or locally following delivery of flagellated derivatives of aroA Salmonella enterica serovar Dublin SL1438 via the nasal route, the most effective mucosal site for activation of immune responses in mice. In contrast, flagellin represents the most potent Salmonella antigen for the generation of specific serum antibody (IgG) responses following i.p. inoculations. The distinct immunogenic properties of Salmonella flagellin could not be ascribed to deficient colonization, reduced invasive ability or loss of the flagellin expression by the flagellated vaccine strains.

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Citations

Jul 13, 2005·Journal of Microbiological Methods·Tine DalbyKaren A Krogfelt
Jan 4, 2008·Journal of Drug Targeting·Bram SlütterWim Jiskoot
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa A CummingsBrad T Cookson
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sukumar SahaKenji Okuda
Mar 28, 2018·Expert Review of Vaccines·Baofeng CuiYonglu Wang
May 2, 2006·Nature Immunology·Naeha Subramanian, Ayub Qadri

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