Flagellin glycosylation with pseudaminic acid in Campylobacter and Helicobacter: prospects for development of novel therapeutics

Cellular and Molecular Life Sciences : CMLS
Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova

Abstract

Many pathogenic bacteria require flagella-mediated motility to colonise and persist in their hosts. Helicobacter pylori and Campylobacter jejuni are flagellated epsilonproteobacteria associated with several human pathologies, including gastritis, acute diarrhea, gastric carcinoma and neurological disorders. In both species, glycosylation of flagellin with an unusual sugar pseudaminic acid (Pse) plays a crucial role in the biosynthesis of functional flagella, and thereby in bacterial motility and pathogenesis. Pse is found only in pathogenic bacteria. Its biosynthesis via six consecutive enzymatic steps has been extensively studied in H. pylori and C. jejuni. This review highlights the importance of flagella glycosylation and details structural insights into the enzymes in the Pse pathway obtained via a combination of biochemical, crystallographic, and mutagenesis studies of the enzyme-substrate and -inhibitor complexes. It is anticipated that understanding the underlying structural and molecular basis of the catalytic mechanisms of the Pse-synthesising enzymes will pave the way for the development of novel antimicrobials.

References

Aug 1, 1992·Journal of Medical Microbiology·K A EatonS Krakowka
Aug 1, 1991·Journal of Bacteriology·P GuerryT J Trust
Aug 1, 1980·Arthritis and Rheumatism·F Y LeungC Bombardier
May 1, 1995·Trends in Microbiology·S Suerbaum
Jun 1, 1995·Infection and Immunity·D J EvansP R Kvietys
May 1, 1993·Journal of Medical Microbiology·G GeisW Opferkuch
Apr 1, 1996·Molecular Microbiology·T L Cover
Oct 23, 1997·Clinical Microbiology Reviews·B E DunnM J Blaser
Apr 4, 1998·Molecular Biology of the Cell·J KriegJ Hofsteenge
Jun 6, 1998·BMJ : British Medical Journal·M J Blaser
Jan 8, 1999·Biochimica Et Biophysica Acta·T R Gemmill, R B Trimble
Jun 11, 1999·Molecular Microbiology·C M SzymanskiP Guerry
Jul 20, 1999·Molecular Microbiology·C JosenhansS Suerbaum
Nov 7, 1999·The Journal of Biological Chemistry·J HofsteengeO Miroshnichenko
Jun 20, 2000·Lancet·D RothenbacherH Brenner
Aug 24, 2000·The Journal of Biological Chemistry·C CreuzenetJ S Lam
Feb 13, 2001·Biophysical Journal·T H Thanka Christlet, K Veluraja
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J A SilvermanP B Harbury
Mar 28, 2001·Science·A Dell, H R Morris
Jul 20, 2001·The Journal of Biological Chemistry·P ThibaultP Guerry
Mar 16, 2002·Infection and Immunity·Karen M Ottemann, Andrew C Lowenthal
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Hermann BrennerTil Stümer
May 15, 2002·International Journal of Medical Microbiology : IJMM·Christine Josenhans, Sebastian Suerbaum
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yanan HuSuzanne Walker
Aug 2, 2003·International Journal of Dermatology·Gabriele ArgenzianoAdone Baroni

❮ Previous
Next ❯

Citations

Feb 9, 2020·International Journal of Molecular Sciences·Chih-Hung WangCheng-Yen Kao
Jan 17, 2020·Chembiochem : a European Journal of Chemical Biology·Emily K P FlackMartin A Fascione
Jul 21, 2020·Scientific Reports·Marie-Josée Haglund HalsørInger Lin Uttakleiv Ræder
Oct 20, 2019·Scientific Reports·Thorsten B BlumJan Pieter Abrahams
Apr 27, 2021·Critical Reviews in Microbiology·Xiaojun MaoFabian Cieplik
Nov 14, 2020·Applied Microbiology and Biotechnology·Vanessa KrelingAndreas Hensel
Jun 16, 2021·Bioorganic & Medicinal Chemistry·Phuong Luong, Danielle H Dube
Sep 1, 2021·Communications Biology·Stephanie PetersMadhusudan Grover
Oct 15, 2021·Frontiers in Microbiology·Vanina Guernier-CambertTorey Looft
Nov 27, 2021·Emerging Microbes & Infections·Jia-Ling YangShan-Chwen Chang

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Related Concepts

Related Feeds

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.