Flagellin peptide flg22 gains access to long-distance trafficking in Arabidopsis via its receptor, FLS2

Journal of Experimental Botany
Joanna JelenskaJean T Greenberg

Abstract

Diverse pathogen-derived molecules, such as bacterial flagellin and its conserved peptide flg22, are recognized in plants via plasma membrane receptors and induce both local and systemic immune responses. The fate of such ligands was unknown: whether and by what mechanism(s) they enter plant cells and whether they are transported to distal tissues. We used biologically active fluorophore and radiolabeled peptides to establish that flg22 moves to distal organs with the closest vascular connections. Remarkably, entry into the plant cell via endocytosis together with the FLS2 receptor is needed for delivery to vascular tissue and long-distance transport of flg22. This contrasts with known routes of long distance transport of other non-cell-permeant molecules in plants, which require membrane-localized transporters for entry to vascular tissue. Thus, a plasma membrane receptor acts as a transporter to enable access of its ligand to distal trafficking routes.

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Citations

May 5, 2018·Plant & Cell Physiology·Isha Sharma, Eugenia Russinova
Oct 15, 2018·The New Phytologist·Satoshi EndoHiroo Fukuda
May 3, 2019·Plant, Cell & Environment·Christian DuttonJulie E Gray
Oct 24, 2019·Molecular Plant-microbe Interactions : MPMI·Natalia Moroz, Kiwamu Tanaka
Sep 19, 2019·Scientific Reports·Sara M WestmanBenedicte R Albrectsen
Apr 24, 2019·International Journal of Molecular Sciences·Artur PinskiRobert Hasterok
Jul 16, 2019·Journal of Experimental Botany·Vardis Ntoukakis, Miriam L Gifford
Jul 25, 2018·Frontiers in Plant Science·Xifeng LiZhixiang Chen
Jan 26, 2021·Plant Science : an International Journal of Experimental Plant Biology·Kou-Cheng PengKuo-Chih Lin

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