Flares in rheumatoid arthritis: frequency and management. A report from the BRASS registry

The Journal of Rheumatology
Vivian BykerkDaniel H Solomon

Abstract

To describe the frequency, duration, and management of flares as reported by patients with rheumatoid arthritis (RA). Data were collected in a prospective observational study of patients with RA recruited from a single academic center and treated according to the rheumatologists' discretion. Every 6 months, patients reported the number and duration of RA flares and described how these were managed in terms of adding or changing medication and use of nonpharmacologic strategies. Of patients who reported flares at least once during the study, 74% reported having flares 6 months prior to study entry and 59% reported flares prior to the first 6-month visit. At subsequent visits, 54-57% reported having > 1 flare. Thirty percent of patients in remission reported flares. Flare duration lasted ≥ 2 weeks in 30%, 1-2 weeks in 13%, and < 1 week in 57%. Forty percent reported medication changes at the time of their flare; 16% changed medication and used nonpharmacologic strategies and 26% of patients reported no changes in treatment as a result of flares. Longer duration of flare was associated with changes in disease-modifying therapy. Patients with RA experienced flares more often when noted to be in higher disease activity states than w...Continue Reading

References

Aug 3, 2011·The Journal of Rheumatology·Rieke AltenUNKNOWN OMERACT RA Flare Definition Working Group
Aug 3, 2011·The Journal of Rheumatology·Clifton O BinghamUNKNOWN OMERACT RA Flare Definition Working Group
Nov 11, 2011·Annals of the Rheumatic Diseases·Jean-Marie BerthelotUNKNOWN STPR group of French Society of Rheumatology
Feb 2, 2012·Annals of the Rheumatic Diseases·Benazir SaleemPaul Emery
Feb 11, 2012·Annals of the Rheumatic Diseases·Clifton O BinghamMaarten P de Wit
Mar 21, 2012·Arthritis Research & Therapy·Femke H M PrinceDaniel H Solomon
Jul 10, 2012·Annals of the Rheumatic Diseases·Susan J BartlettUNKNOWN OMERACT RA Flare Working Group

❮ Previous
Next ❯

Citations

Apr 2, 2016·Current Rheumatology Reports·Sara K Tedeschi, Karen H Costenbader
Feb 4, 2014·The Journal of Rheumatology·Aatke van der Maas, Alfons A den Broeder
Mar 25, 2017·Rheumatology·Christopher J EdwardsKlaus Kruger
Feb 6, 2021·Clinical Rheumatology·Tommaso SchioppoRoberto Caporali

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.