FLASH Radiotherapy: History and Future.

Frontiers in Oncology
Binwei LinXiaobo Du

Abstract

The biological effects of radiation dose to organs at risk surrounding tumor target volumes are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be completely destroyed, and the efficacy of radiotherapy will be decreased. Thus, ways to reduce damage to healthy tissue has always been a topic of particular interest in radiotherapy research. Modern radiotherapy technologies such as helical tomotherapy (HT), intensity-modulated radiation therapy (IMRT), and proton radiotherapy can reduce radiation damage to healthy tissues. Recent outcomes of animal experiments show that FLASH radiotherapy (FLASH-RT) can reduce radiation-induced damage in healthy tissue without decreasing antitumor effectiveness. The very short radiotherapy time compared to that of conventional dose-rate radiotherapy is another advantage of FLASH-RT. The first human patient received FLASH-RT in Switzerland in 2018. FLASH-RT may become one of the main radiotherapy technologies in clinical applications in the future. We summarize the history of the development of FLASH-RT, its mechanisms, its influence on radiotherapy, and its future.

References

Dec 1, 1989·International Journal of Radiation Biology·G G SteelJ H Peacock
Sep 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S B Field, D K Bewley
Jul 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H WeissA Santomasso
Feb 1, 1969·The British Journal of Radiology·R J BerryM J Goodman
Jan 1, 1969·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T PrempreeT Merz
Jan 1, 1971·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S Hornsey, D K Bewley
Sep 19, 2000·International Journal of Radiation Biology·V PonetteV Favaudon
Jan 2, 2001·International Journal of Radiation Biology·M FernetV Favaudon
Mar 30, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thomas E SchmidBarbara Röper
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Yi RongJames Welsh
Oct 20, 2011·Radiation Oncology·Susanne AuerAnna A Friedl
Dec 18, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gustavo Nader MartaRachel Riera
Jul 18, 2014·Science Translational Medicine·Vincent FavaudonMarie-Catherine Vozenin
Mar 25, 2015·Physics in Medicine and Biology·Wayne D Newhauser, Rui Zhang
Aug 19, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·V FavaudonM-C Vozenin
Mar 25, 2016·Nature Reviews. Cancer·Michael BaumannThomas Bortfeld
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Roos LeroyDirk De Ruysscher
May 27, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre Montay-GruelMarie-Catherine Vozenin
Jun 8, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie-Catherine VozeninJean Bourhis
Jul 19, 2018·International Journal of Radiation Oncology, Biology, Physics·Annalisa PatriarcaLudovic De Marzi
Sep 5, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre Montay-GruelMarie-Catherine Vozenin
Dec 6, 2018·Cancer Investigation·Valentina LancellottaCynthia Aristei
Mar 10, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Manuela BuonannoDavid J Brenner
Apr 24, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Douglas R SpitzCharles L Limoli
May 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Pierre Montay-GruelCharles L Limoli
Jun 11, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter G MaximBilly W Loo
Jun 30, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean BourhisMarie-Catherine Vozenin
Jun 30, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Danielle A SimmonsBilly W Loo
Jul 4, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elke BeyreutherJörg Pawelke
Jul 16, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean BourhisMarie-Catherine Vozenin
Dec 5, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles FouilladeVincent Favaudon
Dec 12, 2019·The British Journal of Radiology·Gabriel AdrianKristoffer Petersson
Apr 17, 2020·International Journal of Radiation Oncology, Biology, Physics·Robert J GriffinCharles L Limoli
Oct 20, 2020·International Journal of Radiation Oncology, Biology, Physics·Sara ChabiBenjamin Uzan
Nov 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Young-Eun KimG-One Ahn

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

RT
FLASH
PHASER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physics in Medicine and Biology
Nolan EsplenMagdalena Bazalova-Carter
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jean BourhisMarie-Catherine Vozenin
Clinical Oncology : a Journal of the Royal College of Radiologists
M-C VozeninCharles L Limoli
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Pierre Montay-GruelMarie-Catherine Vozenin
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Christina C Huang, Marc S Mendonca
© 2021 Meta ULC. All rights reserved