Flat bones and sutures formation in the human cranial vault during prenatal development and infancy: A computational model

Journal of Theoretical Biology
F J Burgos-FlórezDiego Alexander Garzon-Alvarado

Abstract

The processes of flat bones growth, sutures formation and interdigitation in the human calvaria are controlled by a complex interaction between genetic, biochemical and environmental factors that regulate bone formation and resorption during prenatal development and infancy. Despite previous experimental evidence accounting for the role of the main biochemical factors acting on these processes, the underlying mechanisms controlling them are still unknown. Therefore, we propose a mathematical model of the processes of flat bone and suture formation, taking into account several biological events. First, we model the growth of the flat bones and the formation of sutures and fontanels as a reaction diffusion system between two proteins: TGF-β2 and TGF-β3. The former is expressed by osteoblasts and allows adjacent mesenchymal cells differentiation on the bone fronts of each flat bone. The latter is expressed by mesenchymal cells at the sutures and inhibits their differentiation into osteoblasts at the bone fronts. Suture interdigitation is modelled using a system of reaction diffusion equations that develops spatio-temporal patterns of bone formation and resorption by means of two molecules (Wnt and Sclerostin) which control mesench...Continue Reading

References

Dec 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L A OppermanR C Ogle
Oct 1, 1993·American Journal of Medical Genetics·M M Cohen
Feb 1, 1996·Bone·M G MullenderP Lips
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A OppermanR C Ogle
Oct 24, 1998·Mechanisms of Development·A L DelezoideJ Bonaventure
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E DennisA I Caplan
Oct 16, 1999·Journal of Morphology·K L Rafferty, S W Herring
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L A Opperman
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A GreenwaldM T Longaker
Apr 24, 2002·Developmental Cell·Gerard Karsenty, Erwin F Wagner
Apr 25, 2003·Developmental Biology·Nicolas HollevilleAnne Hélène Monsoro-Burq
Jan 28, 2004·Cells, Tissues, Organs·Roy C OgleRebecca A Ogle
Jan 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Zongyang SunSusan W Herring
Nov 16, 2004·Bone·C J HernandezM B Schaffler
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
Aug 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenneth E S PooleJonathan Reeve
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
Apr 11, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Craig Daniel Byron
May 3, 2006·Optometry : Journal of the American Optometric Association·Ernest L Bowling, Fernando D Burstein
Aug 22, 2006·Orthodontics & Craniofacial Research·S M AlaqeelL A Opperman
Dec 21, 2007·Differentiation; Research in Biological Diversity·Anna K CoussensAngela van Daal
Feb 19, 2008·Bone·Lynda F Bonewald, Mark L Johnson
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Peter ten DijkeRutger L van Bezooijen
Aug 2, 2008·The American Journal of Pathology·Nadeem SameeMarie-Christine de Vernejoul
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Paul S IssackJoseph M Lane
Apr 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A SantosJ Klein-Nulend
Apr 9, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ana SantosJenneke Klein-Nulend
Jun 9, 2009·Pediatric Clinics of North America·Darren Farley, Donald J Dudley
Oct 9, 2009·Journal of Anatomy·Takashi MiuraKohei Shiota
Dec 3, 2009·Plastic and Reconstructive Surgery·Adam J OppenheimerSteven R Buchman
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Manu S RaamMaximilian Muenke
Nov 3, 2010·Atlas of the Oral and Maxillofacial Surgery Clinics of North America·Jogi V PattisapuBernard J Costello
May 5, 2011·Journal of Anatomy·Christoph P E Zollikofer, John David Weissmann
Jun 30, 2011·Theoretical Biology & Medical Modelling·Diego A Garzón-Alvarado, Angelica M Ramírez Martinez
Sep 13, 2011·Nature Medicine·Tomoki NakashimaHiroshi Takayanagi
Feb 23, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jinhu Xiong, Charles A O'Brien
Nov 21, 2012·The Journal of Craniofacial Surgery·Ryan K WongSteven Roy Cohen
Mar 22, 2013·Proceedings. Biological Sciences·R H KhonsariV Calvez
Apr 23, 2013·Biophysical Journal·Michael B AlbroGerard A Ateshian
May 2, 2013·Seminars in Plastic Surgery·Rebecca M Garza, Rohit K Khosla
Aug 29, 2013·Computer Methods and Programs in Biomedicine·Diego A Garzón-AlvaradoMaria Lucia Gutiérrez

❮ Previous
Next ❯

Citations

Jun 12, 2017·ACS Biomaterials Science & Engineering·Shuo WangFuzhai Cui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Modeling

Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Related Papers

Computer Methods and Programs in Biomedicine
Diego Alexander Garzon-AlvaradoMaría Lucía Gutiérrez
Frontiers in Bioengineering and Biotechnology
Chanyoung LeeReuben H Kraft
International Mechanical Engineering Congress and Exposition : [proceedings]
Chanyoung LeeReuben H Kraft
© 2022 Meta ULC. All rights reserved