Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy

The British Journal of Radiology
Simone SchiaffinoMassimo Calabrese

Abstract

To determine the malignancy rate (defined in this study as stability or absence of malignancy developed on close imaging follow-up post-biopsy) of conservative management in patients with a vacuum-assisted breast biopsy (VAB) diagnosis of flat epithelial atypia (FEA), performed on single group of microcalcifications, completely removed during procedure. This is a retrospective, monocentric, observational study, approved by IRB. Inclusion criteria were: VAB performed on a single group of microcalcifications; the absence of residual calcifications post-VAB; diagnosis of isolated FEA as the most advanced proliferative lesion; radiological follow-up at least of 12 months. The personal history of breast cancer or other high-risk lesions was an exclusion criteria. The patients enrolled were conservatively managed, without surgical excision, through close follow-up: the first two mammographies performed with an interval of 6 months after biopsy, followed by annual mammographic and clinical checks. 48 consecutive patients were enrolled in the study, all females, with age range of 39-76 years (mean 53,3 years) and radiological follow-up range of 13-75 months (mean 41.5 months). All the lesions were classified as BI-RADS 4b. The diameter...Continue Reading

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Citations

Nov 9, 2019·Breast Cancer Research and Treatment·Ashley DiPasqualeLashan Peiris
Oct 15, 2019·The American Journal of Surgical Pathology·Anne GrabenstetterEdi Brogi
Dec 7, 2018·Breast Cancer Research and Treatment·Christoph J RagethZsuzsanna Varga
Apr 20, 2021·JAAPA : Official Journal of the American Academy of Physician Assistants·Katherine B D'AntonioKarlyn Rupert
May 27, 2021·Insights Into Imaging·Francesca CatanzaritiMaria Adele Marino

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