Flat serrated adenomas of the colorectal mucosa

Japanese Journal of Cancer Research : Gann
C A Rubio, E Jaramillo

Abstract

A total of 47 flat serrated neoplasias of the colorectal mucosa are presented: 44 were flat serrated adenomas and the remaining 3 flat serrated adenocarcinomas arising in flat serrated adenomas. These lesions were found among 600 flat mucosal lesions removed at colonoscopy during a 3-year period (1992 and 1994) at the Karolinska Hospital. Thirty-five of the 47 patients (74%) were males and the remaining 12 (26%), females. Depending upon the degree of cellular dysplasia within the epithelium, serrated adenomas were divided into those with low-grade dysplasia (LGD), when the dysplastic nuclei were present in the deeper half of the epithelium, and those with high-grade dysplasia (HGD), when the dysplastic nuclei were found even in the upper half of the epithelium. LGD was present in 37 (84.1%) of the 44 serrated adenomas and HGD in the remaining 7 (15.9%). Depending upon the topographic distribution of the dysplastic epithelium within the crypts, flat serrated adenomas were divided into type I, when the dysplastic epithelium was limited to the lower half of the serrated crypts, and type II, when the dysplastic epithelium was even present in the superficial half of the serrated crypts. Of the 44 serrated adenomas, 38 (86.1%) were t...Continue Reading

References

Jan 1, 1991·Human Pathology·R A Wolber, D A Owen
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Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·C A Rubio, M Rodensjö
May 1, 1994·Journal of Surgical Oncology·C RubioE Jaramillo

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Citations

Aug 1, 1996·Japanese Journal of Cancer Research : Gann·C A RubioT Muto
Mar 10, 2017·Scandinavian Journal of Gastroenterology·Henrik ThorlaciusErvin Toth
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Sang Yong SongJong Chul Rhee
Mar 24, 2011·The American Journal of Gastroenterology·Yuichiro YanoMichio Imawari
Nov 24, 2004·The American Journal of Gastroenterology·Christopher S HuangFrancis A Farraye
Apr 21, 2006·Journal of Health Communication·Annabelle Mooney
Oct 1, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaHisao Tajiri
Feb 6, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaHisao Tajiri
Nov 4, 2010·The American Journal of Gastroenterology·Christopher S HuangMichael J O'Brien
Dec 23, 2020·Archives of Pathology & Laboratory Medicine·Adam L BoothRaul S Gonzalez

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