Flat Serrated Polyps at CT Colonography: Relevance, Appearance, and Optimizing Interpretation

Radiographics : a Review Publication of the Radiological Society of North America, Inc
David H KimPerry J Pickhardt


Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation. These lesions are often flat-only minimally raised from the colonic surface-and occur in the right colon. These lesions have been a likely common cause of screening failure at colonoscopy, although detection has improved with improved recognition over time. Although detection is difficult with image-based screening, serrated lesions can be detected at CT colonography. The prevalence in CT colonography screening populations mirrors the rates at colonoscopy for similar size categories. CT colonography allows identification of SSPs despite their minimally raised profile owing to the phenomenon of lesional contrast material coating. This contrast material coat aids in lesion detection by highlighting the subtle morp...Continue Reading


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