Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

European Journal of Medicinal Chemistry
Canan G NebigilLaurent Désaubry

Abstract

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Citations

Oct 10, 2020·Bioorganic & Medicinal Chemistry Letters·Dong WangLaurent Désaubry
Apr 23, 2021·Chemico-biological Interactions·Amgad M Rabie
Nov 2, 2020·European Journal of Medicinal Chemistry·Redouane TabtiLaurent Désaubry
May 8, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Khadga RajShamsher Singh
Jul 27, 2021·Journal of Molecular Structure·Amgad M Rabie

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Methods Mentioned

BETA
deamination
transfection

Software Mentioned

eFFECTOR

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