Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes

Journal of Natural Products
Yun-Ju KwonWon-Gon Kim

Abstract

Flavimycins A (1) and B (2), novel dimeric 1,3-dihydroisobenzofurans, were isolated as inhibitors of peptide deformylase from cultures of Aspergillus flavipes. Their chemical structures were established by NMR and MS data analysis. Compounds 1 and 2 exist as epimeric mixtures at C-1 through fast hemiacetal-aldehyde tautomerism. Compounds 1 and 2 inhibited Staphylococcus aureus peptide deformylase with IC₅₀ values of 35.8 and 100.1 μM, respectively. Consistent with their PDF inhibition, 1 showed two times stronger antibacterial activity than 2 on S. aureus including MRSA, with MIC values of 32-64 μg/mL.

References

Sep 8, 2001·Drug Discovery Today·Z YuanR J. White
Sep 3, 2003·Bioorganic & Medicinal Chemistry Letters·Wataru TakayamaJun Inoue
Nov 19, 2003·Bioorganic & Medicinal Chemistry Letters·R JainZ Yuan
Dec 4, 2004·Nature Medicine·Stuart B Levy, Bonnie Marshall
Jul 19, 2005·Current Medicinal Chemistry·R JainZ Yuan
Sep 8, 2005·Expert Opinion on Investigational Drugs·D Chen, Z Yuan
Jul 1, 2006·Bioorganic & Medicinal Chemistry Letters·Jung-Sung YooWon-Gon Kim
Dec 28, 2006·Journal of Natural Products·Chang-Ji ZhengWon-Gon Kim
Jun 28, 2011·The Journal of Antimicrobial Chemotherapy·David M Livermore
Jun 28, 2011·The Journal of Antimicrobial Chemotherapy·Richard Wise

❮ Previous
Next ❯

Citations

Jun 20, 2014·Natural Product Research·Jinzhong XuXianwen Yang
Sep 27, 2014·Chemical Communications : Chem Comm·Dixit Parmar, Magnus Rueping
Jul 16, 2020·Life·Cristina VisentinStefano Ricagno
Sep 17, 2013·Journal of Natural Products·Bo WangXiao-Ning Wang
Sep 11, 2021·Organic Letters·Caifang HanHaifeng Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.