PMID: 8589063Jan 1, 1995Paper

Flavocytochrome b2-cytochrome c interactions: the electron transfer reaction revisited

Biochimie
C Capeillère-Blandin

Abstract

This review is concerned with the kinetics and mechanism of electron transfer processes which occur intermolecularly between reduced flavocytochrome b2 and cytochrome c molecules within an encounter complex. Analyses are given of previous reports which aimed at describing the formation of stable complexes obtained at low ionic strength in solution and in the crystalline state with a binding stoichiometry of 1 to 1 heme ratio. Relevant data allow to define the respective role of flavin and heme b2 in the electron transfer towards cytochrome c and give a description of the recognition areas on the two redox partners. The paper also refers to a recent computer model of their postulated interactions as based on the three-dimensional structure of the Saccharomyces cerevisiae single molecules. Special emphasis is given to rapid kinetic investigations of the electron transfer reaction between Hansenula anomala flavocytochrome b2 and cytochrome c studied as a function of concentration, ionic strength and temperature. Data showed that reaction rates were modulated by ionic strength, reaching a saturation behaviour at low ionic strength. In the present paper the temperature effects on Kd and kET have been re-examined. Thermodynamic analy...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·F LabeyrieF Lederer
Dec 15, 1979·Journal of Molecular Biology·B Guiard, F Lederer
Aug 22, 1977·Biochemical and Biophysical Research Communications·M GervaisF Labeyrie
Aug 28, 1975·Nature·C Chothia, J Janin
Aug 1, 1975·European Journal of Biochemistry·C Capeillère-Blandin
Feb 27, 1992·Nature·C C MoserP L Dutton
Jan 1, 1992·Annual Review of Biophysics and Biomolecular Structure·J N OnuchicH B Gray
Apr 20, 1990·Journal of Molecular Biology·Z X Xia, F S Mathews
Feb 15, 1989·The Biochemical Journal·M T BlackS K Chapman
Nov 17, 1987·Biochemistry·F GuerlesquinM Bruschi
Aug 29, 1986·Science·S L MayoH B Gray
Jun 30, 1987·Biochemical and Biophysical Research Communications·M A ThomasJ Y Lallemand
Dec 15, 1988·European Journal of Biochemistry·G A ReidS K Chapman
Nov 5, 1988·Journal of Molecular Biology·J JaninC Chothia
Jan 1, 1988·Annals of the New York Academy of Sciences·J A CowanH B Gray
Mar 23, 1988·Biochimica Et Biophysica Acta·F LabeyrieM A Thomas
Oct 15, 1985·European Journal of Biochemistry·F LedererL Perez
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·B GuiardF Lederer
Jan 31, 1972·European Journal of Biochemistry·C Jacq, F Lederer
Nov 1, 1974·European Journal of Biochemistry·P Pajot, M L Claisse
Jan 16, 1974·European Journal of Biochemistry·C Jacq, F Lederer

❮ Previous
Next ❯

Citations

Apr 20, 2011·European Biophysics Journal : EBJ·Florence Lederer
May 4, 2011·Journal of the American Chemical Society·Agnieszka A ZiebaJohannes P M Schelvis
Aug 5, 2009·Journal of Inorganic Biochemistry·Rui M AlmeidaJosé J G Moura
Oct 14, 2009·Biochemistry·K H Diêp LêFlorence Lederer
Apr 28, 2004·Bioorganic Chemistry·Ram SinghS M S Chauhan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.